Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2021; 13(6): 620-633
Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.620
Glutathione-S-transferases genes-promising predictors of hepatic dysfunction
Vasyl Prysyazhnyuk, Larysa Sydorchuk, Ruslan Sydorchuk, Iryna Prysiazhniuk, Kateryna Bobkovych, Inna Buzdugan, Valentina Dzuryak, Petro Prysyazhnyuk
Vasyl Prysyazhnyuk, Kateryna Bobkovych, Department of Propedeutics of Internal Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine
Larysa Sydorchuk, Valentina Dzuryak, Department of Family Medicine, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine
Ruslan Sydorchuk, Department of Surgery, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine
Iryna Prysiazhniuk, Inna Buzdugan, Department of Internal Medicine and Invectious Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine
Petro Prysyazhnyuk, Department of Medical and Pharmaceutical Chemistry, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine
Author contributions: Prysyazhnyuk V was responsible for conception and design, analysis and interpretation of the clinical data, critical revision of the manuscript, final approval of the article; Sydorchuk L, Sydorchuk R analysed and interpreted of the pathophysiological data, critical revision of the manuscript, final approval of the article; Prysiazhniuk I was responsible for acquisition of data, drafting of the article, critical revision of the manuscript, final approval of the article; Bobkovych K, Buzdugan I, Dzhuryak V, and Prysyazhnyuk P were responsible for acquisition of data, critical revision of the manuscript, final approval of the article.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vasyl Prysyazhnyuk, DSc, MD, PhD, Professor of the Department of Propedeutics of Internal Diseases, Bukovinian State Medical University, Teatralna square 2, Chernivtsi 58002, Chernivtsi region, Ukraine. prysyaznyuk_v@ukr.net
Received: March 17, 2021
Peer-review started: March 17, 2021
First decision: May 2, 2021
Revised: May 6, 2021
Accepted: June 3, 2021
Article in press: June 3, 2021
Published online: June 27, 2021
Processing time: 97 Days and 6.3 Hours
Core Tip

Core Tip: Current review provide data regarding impact of genetic polymorphism of glutathione-S-transferase (GST) genes in the pathogenesis of various liver diseases, particularly non-alcoholic fatty liver disease, hepatitis and liver cirrhosis of different etiology and hepatocellular carcinoma. Certain GST allelic variants were proven to be associated with susceptibility to hepatological pathology and correlations with the natural course of the diseases were subsequently postulated.