Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2021; 13(4): 393-410
Published online Apr 27, 2021. doi: 10.4254/wjh.v13.i4.393
Pathologic and molecular features of hepatocellular carcinoma: An update
Mukul Vij, Julien Calderaro
Mukul Vij, Department ofPathology, Dr Rela Institute and Medical Center, Chennai 600044, Tamil Nadu, India
Julien Calderaro, Department of Pathology, Groupe Hospitalier Henri Mondor, Creteil F-94010, France
Author contributions: Vij M and Calderaro J conceptualized and designed the study, performed literature review and drafting of the manuscript; both authors approved the manuscript for publication.
Conflict-of-interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mukul Vij, MD, PDCC, Senior Consultant Pathologist, Department of Pathology, Dr Rela Institute and Medical Center, #7, CLC Works Road, Chromepet, Chennai 600044, Tamil Nadu, India.
Received: December 20, 2020
Peer-review started: December 20, 2020
First decision: January 7, 2021
Revised: January 27, 2021
Accepted: March 31, 2021
Article in press: March 31, 2021
Published online: April 27, 2021
Core Tip

Core Tip: We summarize several new distinct histologic subtypes of hepatocellular carcinoma (HCC) and recurrent molecular alterations in HCC. Major histologic subtypes like macrotrabecular massive, fibrolamellar HCC, steatohepatitic HCC, scirrhous HCC, lymphoepithelioma-like HCC, and combined hepatocellaular-cholangiocarcinoma are discussed in detail. Rare and provisional histological variants are also discussed.