Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2013
Peer-review started: May 18, 2021
First decision: June 15, 2021
Revised: June 23, 2021
Accepted: November 27, 2021
Article in press: October 27, 2021
Published online: December 27, 2021
Core Tip: The study evaluated the incidence of liver injury in coronavirus disease 2019 (COVID-19) patients and its impact on clinical outcomes and pathophysiological mechanism of liver injury. More than one-fourth of COVID-19 patients had suffered from liver injury, mostly a mild-to-moderate liver dysfunction. Liver involvement is independently associated with adverse clinical outcomes. Direct viral cytotoxic effect, complications of the disease, and drugs used in the treatments are the pathophy