Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2021; 13(12): 1968-1976
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1968
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1968
Dengue hemorrhagic fever and the liver
Wattana Leowattana, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Bangkok, Thailand
Tawithep Leowattana, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Bangkok, Thailand
Author contributions: Leowattana W wrote the paper; Leowattana T collected the data.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wattana Leowattana, BSc, MD, MSc, PhD, Associate Professor, Senior Researcher, Staff Physician, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Rachatawee, Bangkok 10400, Bangkok, Thailand. wattana.leo@mahidol.ac.th
Received: March 5, 2021
Peer-review started: March 5, 2021
First decision: March 29, 2021
Revised: March 30, 2021
Accepted: November 13, 2021
Article in press: November 13, 2021
Published online: December 27, 2021
Peer-review started: March 5, 2021
First decision: March 29, 2021
Revised: March 30, 2021
Accepted: November 13, 2021
Article in press: November 13, 2021
Published online: December 27, 2021
Core Tip
Core Tip: The liver is the most common organ involvement in dengue hemorrhagic fever (DHF) patients with ranges from mild subclinical biochemical changes to severe liver disease as an acute liver failure (ALF). However, the low incidence of ALF in DHF with liver injury is associated with a high fatality rate. The hepatocyte injury is caused by direct viral cytopathic, immune-mediated, and poor hepatic perfusion. Early detection of severe hepatocellular injury development may reduce the morbidity and mortality in DHF patients with liver involvement.