Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1909
Peer-review started: February 25, 2021
First decision: May 3, 2021
Revised: May 7, 2021
Accepted: November 24, 2021
Article in press: November 24, 2021
Published online: December 27, 2021
Core Tip: The frequency of abnormalities in liver function tests (LFTs) in coronavirus disease 2019 (COVID-19) infected patients increases with age and is observed in males more than females. A pre-existing history of liver disease and comorbidity increases LFT abnormality and the likelihood of severe liver damage in COVID-19 infection. Antiviral treatment and treatment of comorbid diseases intensifies the hepatotoxic effect on the liver, which often manifests itself in higher levels in LFTs.