Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 27, 2021; 13(11): 1534-1551
Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1534
Liver involvement in inflammatory bowel disease: What should the clinician know?
Giuseppe Losurdo, Irene Vita Brescia, Chiara Lillo, Martino Mezzapesa, Michele Barone, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo, Maria Rendina
Giuseppe Losurdo, Irene Vita Brescia, Chiara Lillo, Martino Mezzapesa, Michele Barone, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo, Maria Rendina, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy
Author contributions: Losurdo G, Di Leo A and Rendina M planned the study; Brescia IV, Losurdo G, Lillo C and Mezzapesa M wrote the text; Principi M, Barone M and Rendina M critically revised the article; all the authors read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuseppe Losurdo, MD, Doctor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Pzza Giulio Cesare, Bari 70124, Italy. giuseppelos@alice.it
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: May 3, 2021
Revised: May 6, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 27, 2021
Processing time: 271 Days and 16.6 Hours
Core Tip

Core Tip: In the present article, several aspects of liver involvement of inflammatory bowel disease (IBD) have been highlighted. Co-occurrence of primary sclerosing cholangitis is one of the most well-known comorbidities and deserves more attention by the clinician. Liver damage due to drugs used to cure IBD is also a relevant issue. Finally, some emerging topics such as the spread of liver steatosis or the implications of chronic viral hepatitis have been analyzed.