Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2021; 13(10): 1450-1458
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1450
Focal nodular hyperplasia associated with a giant hepatocellular adenoma: A case report and review of literature
Sérgio Gaspar-Figueiredo, Amaniel Kefleyesus, Christine Sempoux, Emilie Uldry, Nermin Halkic
Sérgio Gaspar-Figueiredo, Amaniel Kefleyesus, Emilie Uldry, Nermin Halkic, Department of Visceral Surgery, Lausanne University Hospital, Lausanne 1011, Switzerland
Christine Sempoux, Department of Pathology, Lausanne University Hospital, Lausanne 1011, Switzerland
Author contributions: Gaspar-Figueiredo S and Kefleyesus A performed the literature review, collected all the data related to the case report, and recorded/edited the video-vignette related to the case report; Sempoux C did the anatomopathological examination/appraisal; Halkic N and Uldry E did the surgical appraisal; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Nermin Halkic, MD, PhD, Chief Doctor, Professor, Department of Visceral Surgery, Lausanne University Hospital, Rue du Bugnon 46, Lausanne 1011, Switzerland.
Received: April 25, 2021
Peer-review started: April 25, 2021
First decision: June 4, 2021
Revised: June 15, 2021
Accepted: August 31, 2021
Article in press: August 31, 2021
Published online: October 27, 2021
Core Tip

Core Tip: Focal nodular hyperplasia and hepatocellular adenoma (HCA) are frequent but non-malignant tumors. There is rarely indication for surgery. Combination of these two masses is a very unusual situation. Their diagnosis is mainly based on radiology. Oral contraception is a risk factor for HCA. Malignant transformation of HCA is the predominant argument for surgery. All these cases, especially composite tumors, must be discussed in a multidisciplinary team.