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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2021; 13(10): 1299-1315
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1299
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1299
Coronavirus disease 2019 in liver transplant patients: Clinical and therapeutic aspects
Carmelo Loinaz-Segurola, Alberto Marcacuzco-Quinto, HBP and Transplant Surgery Unit. Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario “12 de Octubre”, Instituto de Investigación Sanitaria Hospital “12 de Octubre” (imas12), Universidad Complutense, Madrid 28041, Spain
Mario Fernández-Ruiz, Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital “12 de Octubre” (imas12), Universidad Complutense, Madrid 28041, Spain
Author contributions: Loinaz-Segurola C and Marcacuzco-Quinto A performed the literature review on the clinical aspects and wrote the related text; Fernández-Ruiz M reviewed mainly the therapeutics issues and wrote the related text; All the authors reviewed the paper and approve the final manuscript.
Conflict-of-interest statement: The authors declare that there are no any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carmelo Loinaz-Segurola, FACS, MD, PhD, Associate Professor, HBP and Transplant Surgery Unit. Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario “12 de Octubre”, Instituto de Investigación Sanitaria Hospital “12 de Octubre” (imas12), Universidad Complutense, Avenida de Cordoba s/n, Madrid 28041, Spain. cloinaz@ucm.es
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: June 4, 2021
Revised: June 17, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: October 27, 2021
Processing time: 242 Days and 19.7 Hours
Peer-review started: February 21, 2021
First decision: June 4, 2021
Revised: June 17, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: October 27, 2021
Processing time: 242 Days and 19.7 Hours
Core Tip
Core Tip: Coronavirus disease 2019 incidence and clinical and radiological features are similar in liver transplant recipients and the general population. Reported mortality in hospitalized patients is 12%-19%. Risk factors are older age and comorbidity. Tacrolimus could be protective, but anti-proliferative agents such as mycophenolate mofetil should be avoided.