Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2021; 13(1): 94-108
Published online Jan 27, 2021. doi: 10.4254/wjh.v13.i1.94
Integrative analysis of layers of data in hepatocellular carcinoma reveals pathway dependencies
Mamatha Bhat, Elisa Pasini, Chiara Pastrello, Sara Rahmati, Marc Angeli, Max Kotlyar, Anand Ghanekar, Igor Jurisica
Mamatha Bhat, Elisa Pasini, Marc Angeli, Multi Organ transplant Program, University Health Network, Toronto M5G2N2, Canada
Chiara Pastrello, Sara Rahmati, Max Kotlyar, Igor Jurisica, Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health NetworkandKrembil Research Institute, University Health Network, Toronto M5T 0S8, Canada
Anand Ghanekar, Surgery, University Health Network, Toronto M5G 2C4, Canada
Igor Jurisica, Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto M5T 0S8, Canada
Author contributions: Bhat M, Pasini E, Kotlyar M and Jurisica I study design, and writing of the manuscript; Bhat M, Pasini E, and Angeli M data collection, analysis and compilation; Ghanekar A, Jurisica I and Bhat M input into study design, data interpretation and final manuscript. All authors approved the final version of the manuscript.
Institutional review board statement: All data was from publicly available sources, no animal or human studies where done by the authors. No approval was needed. 
Conflict-of-interest statement: The authors do not have any conflict of interest to declare.
Data sharing statement: Technical appendix, statistical code available from the corresponding author at all data sets are publicly available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mamatha Bhat, MD, MSc, PhD, FRCPC(C) Assistant Professor, Staff Physician, Multi Organ transplant Program, University Health Network, 585 University avenue 11th floor, PMB, rm 183, Toronto M5G2N2, Canada.
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: September 21, 2020
Revised: November 19, 2020
Accepted: December 4, 2020
Article in press: December 4, 2020
Published online: January 27, 2021
Core Tip

Core Tip: Analyzing all available high-throughput genomic, transcriptomic, miRNA, methylation and proteomic data from human hepatocellular carcinoma tissue, we identified master regulators of key pathways in hepatocellular carcinoma, such as the mTOR, Ras/Raf/MAPK and p53 pathways.