Tan HK, Streeter A, Cramp ME, Dhanda AD. Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis. World J Hepatol 2020; 12(7): 389-398 [PMID: 32821337 DOI: 10.4254/wjh.v12.i7.389]
Corresponding Author of This Article
Ashwin D Dhanda, BSc, MBChB, MRCP, PhD, Associate Professor, Consultant and Honorary Associate Professor in Hepatology, Hepatology Research Group, Institute of Translational and Stratified Medicine, Faculty of Health, University of Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, United Kingdom. ashwin.dhanda@plymouth.ac.uk
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 27, 2020; 12(7): 389-398 Published online Jul 27, 2020. doi: 10.4254/wjh.v12.i7.389
Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis
Huey K Tan, Adam Streeter, Matthew E Cramp, Ashwin D Dhanda
Huey K Tan, Matthew E Cramp, Ashwin D Dhanda, South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, United Kingdom
Huey K Tan, Matthew E Cramp, Ashwin D Dhanda, Hepatology Research Group, Institute of Translational and Stratified Medicine, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, United Kingdom
Adam Streeter, Medical Statistics Group, Faculty of Health, University of Plymouth, Plymouth PL6 8BU, United Kingdom
Author contributions: Dhanda AD conceived the study. Tan HK, Dhanda AD and Cramp ME performed the research. Streeter A analysed the data; Tan HK wrote the manuscript. Dhanda AD and Cramp ME supervised the paper; all authors read and approved the final manuscript.
Conflict-of-interest statement: None of the authors have any relevant conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors confirm that the manuscript was prepared and revised according to the PRISMA 2009 Checklist for this meta-analysis.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ashwin D Dhanda, BSc, MBChB, MRCP, PhD, Associate Professor, Consultant and Honorary Associate Professor in Hepatology, Hepatology Research Group, Institute of Translational and Stratified Medicine, Faculty of Health, University of Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, United Kingdom. ashwin.dhanda@plymouth.ac.uk
Received: March 30, 2020 Peer-review started: March 30, 2020 First decision: April 22, 2020 Revised: June 4, 2020 Accepted: June 10, 2020 Article in press: June 10, 2020 Published online: July 27, 2020 Processing time: 114 Days and 15.8 Hours
Core Tip
Core tip: Zinc deficiency is highly prevalent in patients with cirrhosis and may contribute to disease progression and mortality. This systematic review aimed to determine whether zinc supplementation was associated with clinical outcomes in patients with cirrhosis. Meta-analysis of data from four eligible studies found that zinc supplementation was not associated with reduced mortality at 6 mo. No study reported changes in disease severity or complications. Eligible studies were highly heterogeneous with different zinc formulations, dosage and duration applied to varying patient populations. Further well-designed prospective studies are required to determine whether zinc supplementation improves long-term clinical outcome in patients with cirrhosis.
