Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 27, 2020; 12(5): 207-219
Published online May 27, 2020. doi: 10.4254/wjh.v12.i5.207
Drug and herbal/dietary supplements-induced liver injury: A tertiary care center experience
Ayesha S Siddique, Osama Siddique, Michael Einstein, Eva Urtasun-Sotil, Saverio Ligato
Ayesha S Siddique, Saverio Ligato, Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT 06102, United States
Osama Siddique, Michael Einstein, Eva Urtasun-Sotil, Department of Gastroenterology and Hepatology, Hartford Hospital, University of Connecticut, Hartford, CT 06102, United States
Author contributions: Siddique AS and Ligato S designed the study, collected and reviewed the cases and wrote the manuscript; Siddique O, Einstein M and Urtasun-Sotil E contributed to the design, analysis and final revision of the manuscript.
Institutional review board statement: This study was approved by the IRB at Hartford Hospital.
Informed consent statement: Patients were not required to give consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ayesha S Siddique, MD, Doctor, Department of Pathology and Laboratory Medicine, Hartford Hospital, 85 Seymour Street, Hartford, CT 06102, United States.
Received: December 18, 2019
Peer-review started: December 18, 2019
First decision: January 5, 2020
Revised: March 26, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: May 27, 2020
Core Tip

Core tip: This a retrospective study to evaluate the clinicopathological patterns of drug and herbal/dietary supplement related injury with only reports of proven cases from a large cohort of patients. We describe many unusual patterns of injury as well as newer drugs/herbals causing previously unreported patterns of injury. Drug/Herbal dietary supplements related liver injury is a well-reported topic, but it is important to report newer patterns in this changing era of medicine.