Published online May 27, 2020. doi: 10.4254/wjh.v12.i5.184
Peer-review started: October 23, 2019
First decision: November 22, 2019
Revised: March 25, 2020
Accepted: March 30, 2020
Article in press: March 30, 2020
Published online: May 27, 2020
Core tip: Recently, cytoprotective agent BPC 157 successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein) through rapid collateral vessel recruitment to circumvent vessel occlusion. Medication BPC 157 [(10 µg, 10 ng/kg) regimens, administered as a single challenge] picked (1) ischemia, portal triad obstruction (PTO) period [at 5 min before (ip) or at 5 or 30 min of ligation time (as a bath to PTO)] or (2) reperfusion, post-PTO period [at 1 or 15 min (bath during surgery) or 24 h (ip) reperfusion time]. Gross, microscopy, malondialdehyde, serum enzymes, electrocardiogram, portal, caval and aortal pressure, thrombosis and venography assessments demonstrated that BPC 157 successfully attenuates ischemia-reperfusion injury of the liver and other organs. In particular, BPC 157 rapidly activates portocaval shunt, normalises arterial and disturbed blood pressure (portal and caval hypertension and aortal hypotension), counteracts formation of blood clots and cardiac rhythm changes and counteracts gastrointestinal mucosal lesions, as complications that follow the Pringle maneuver.