Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2020; 12(3): 108-115
Published online Mar 27, 2020. doi: 10.4254/wjh.v12.i3.108
Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature
Motasem Alkhayyat, Mohannad Abou Saleh, Mohammad Zmaili, Vedha Sanghi, Tavankit Singh, Carol Rouphael, C Roberto Simons-Linares, Carlos Romero-Marrero, William D Carey, Christina C Lindenmeyer
Motasem Alkhayyat, Mohammad Zmaili, Vedha Sanghi, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Mohannad Abou Saleh, Tavankit Singh, Carol Rouphael, C Roberto Simons-Linares, Carlos Romero-Marrero, William D Carey, Christina C Lindenmeyer, Digestive Disease & Surgery Institute, Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Alkhayyat M, Saleh MA, Zmaili M and Sanghi V reviewed the literature and contributed to manuscript drafting; Singh T, Rouphael C, Simons-Linares CR, Romero-Marrero C, Carey WD and Lindenmeyer CC reviewed and contributed to the manuscript; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Christina C Lindenmeyer, MD, Staff Physician, Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, 9500 Euclid Ave Mail Code A51, Cleveland, OH 44195, United States. lindenc@ccf.org
Received: September 13, 2019
Peer-review started: September 13, 2019
First decision: September 26, 2019
Revised: December 28, 2019
Accepted: February 17, 2020
Article in press: February 17, 2020
Published online: March 27, 2020
Processing time: 192 Days and 12.7 Hours
Core Tip

Core tip: Acute sickle cell intrahepatic cholestasis is a rare and life-threatening form of sickle cell hepatopathy, with a mortality rate approaching 40%. Patients typically present with fever, abdominal pain and jaundice. Rarely, it may progress to an acute liver failure phenotype, commonly associated with multi-system organ failure. Diagnosis is made after excluding other causes of acute liver injury. Treatment options include exchange blood transfusion and liver transplantation.