Minireviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2020; 12(12): 1182-1197
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1182
Liver injury in COVID-19: The hepatic aspect of the respiratory syndrome — what we know so far
Prajna Anirvan, Pankaj Bharali, Mrinal Gogoi, Paul J Thuluvath, Shivaram P Singh, Sanjaya K Satapathy
Prajna Anirvan, Department of Gastroenterology, Sriram Chandra Bhanj Medical College, Cuttack 753007, Odisha, India
Pankaj Bharali, Mrinal Gogoi, Shivaram P Singh, Department of Gastroenterology, Sriram Chandra Bhanj Medical College and Hospital, Cuttack 753007, Odisha, India
Paul J Thuluvath, Department of Surgery and Medicine, Mercy Medical Center, Baltimore, MD 21202, United States
Sanjaya K Satapathy, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, NY 11030, United States
Author contributions: Singh SP and Satapathy SK contributed to the conception and design of the manuscript; Singh SP, Satapathy SK, Thuluvath PJ, Anirvan P, Bharali P and Gogoi M drafted the initial manuscript; All authors participated in the critical revision of the manuscript for important intellectual contents and approved the final manuscript.
Supported by Kalinga Gastroenterology Foundation, Cuttack, India.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sanjaya K Satapathy, FAASLD, AGAF, FACG, FASGE, Medical Director Liver Transplantation, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, 400 Community Drive, Manhasset, NY 11030, United States. ssatapat@northwell.edu
Received: September 6, 2020
Peer-review started: September 6, 2020
First decision: October 5, 2020
Revised: October 21, 2020
Accepted: November 17, 2020
Article in press: November 17, 2020
Published online: December 27, 2020
Processing time: 102 Days and 18.3 Hours
Core Tip

Core Tip: Hepatic injury in coronavirus disease 2019 (COVID-19) has been widely observed. Although the pathogenic mechanisms still remain unclear, it is believed to be due to interplay of multiple factors. In this review, we have tried to discuss the pathophysiological mechanisms of hepatic injury in the context of COVID-19 and have proposed a management outline of such injury.