Gupta A, Pandey A. Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid. World J Hepatol 2020; 12(11): 949-964 [PMID: 33312421 DOI: 10.4254/wjh.v12.i11.949]
Corresponding Author of This Article
Abhay K Pandey, PhD, Professor, Department of Biochemistry, University of Allahabad, Prayagraj - 211002, Uttar Pradesh, India. akpandey23@rediffmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Nov 27, 2020; 12(11): 949-964 Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.949
Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid
Ashutosh Gupta, Abhay K Pandey
Ashutosh Gupta, Abhay K Pandey, Department of Biochemistry, University of Allahabad, Prayagraj 211002, Uttar Pradesh, India
Author contributions: Pandey AK conceptualized and designed the study; Gupta A performed the experiments, collected the data, and wrote the manuscript; Gupta A and Pandey AK analyzed and interpreted the data; Pandey AK critically reviewed and finalized the manuscript. All authors have read and approved the final manuscript.
Institutional animal care and use committee statement: The study was reviewed and approved by the Institutional Animal Ethics Committee, University of Allahabad, Prayagraj, India (IAEC/AU/2019(1)/16).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abhay K Pandey, PhD, Professor, Department of Biochemistry, University of Allahabad, Prayagraj - 211002, Uttar Pradesh, India. akpandey23@rediffmail.com
Received: June 16, 2020 Peer-review started: June 16, 2020 First decision: August 22, 2020 Revised: September 5, 2020 Accepted: September 22, 2020 Article in press: September 22, 2020 Published online: November 27, 2020
Core Tip
Core Tip: Hepatotoxicity is the most serious adverse effects of aceclofenac (ACF). In this study, ACF-induced hepatic damage in rats was investigated. ACF administration (15 mg/kg/d) for 21 d produced severe hepatotoxicity and oxidative stress as demonstrated by abnormal elevations in serum and tissue markers. Co-administration of Terminalia bellirica fruit extracts (200 mg/kg) and ellagic acid (40 mg/kg) significantly attenuated ACF-induced hepatotoxicity. These results showed that supplementation with the test compounds led to restoration of serum liver function markers (SGOT, GPT, GGT, LDH, ALP, total protein, urea, uric acid, creatinine) and hepatic antioxidant status (superoxide dismutase, catalase, TBARS). Hence T. bellirica fruit extracts and ellagic acid have the potential to act as a hepatoprotectant and antioxidant in the treatment of drug-induced hepatotoxicity and oxidative stress. To the best of our knowledge, this is the first study to evaluate the therapeutic efficacy of T. bellirica fruit extracts and ellagic acid as hepatoprotective agents against ACF-induced hepatotoxicity.
