Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 27, 2020; 12(11): 1055-1066
Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.1055
Non-invasive splenic parameters of portal hypertension: Assessment and utility
Ayesha Karim Ahmad, Sebastiana Atzori, James Maurice, Simon D Taylor-Robinson, Adrian KP Lim
Ayesha Karim Ahmad, Liver Unit, Department of Digestion, Metabolism & Reproduction, Faculty of Medicine, Imperial College London, London W2 1NY, United Kingdom
Sebastiana Atzori, James Maurice, Simon D Taylor-Robinson, Liver Unit, Department of Digestion, Metabolism & Reproduction, Imperial College London, London W2 1NY, United Kingdom
Adrian KP Lim, Liver Unit and Imaging, Department of Digestion, Metabolism & Reproduction, Imperial College London, London W2 1NY, United Kingdom
Author contributions: Ahmad AK collected data, performed statistical analyses, wrote the manuscript with support from other authors; Atzori S performed the experiments and statistical analyses; Maurice J critically appraised study design; Taylor-Robinson SD and Lim AKP designed, supervised and implemented the research; all authors discussed the results and contributed to the final manuscript.
Institutional review board statement: This study was performed in accordance with the 1975 Declaration of Helsinki, with approvals from the Research Ethics Committee and the Joint Research and Compliance Office of Imperial College London and Imperial College Healthcare NHS Trust.
Informed consent statement: Patients were required to give informed consent to the study in the form of written consent.
Conflict-of-interest statement: This work was supported by Philips Medical Systems (Seattle, Washington, United States); United Kingdom National Institute for Health Research Biomedical Facility at Imperial College London, London, United Kingdom.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Adrian KP Lim, MD FRCR, Doctor, Liver Unit and Imaging, Department of Digestion, Metabolism & Reproduction, Imperial College London, London W2 1NY, United Kingdom. a.lim@imperial.ac.uk
Received: July 16, 2020
Peer-review started: July 16, 2020
First decision: August 9, 2020
Revised: August 22, 2020
Accepted: October 9, 2020
Article in press: October 9, 2020
Published online: November 27, 2020
Processing time: 130 Days and 15.1 Hours
Core Tip

Core Tip: Non-invasive splenic parameters are useful surrogate markers of portal hypertension (PH). A combination of spleen diameter, spleen area, liver stiffness and aspartate aminotransferase-to-platelet-ratio-index (APRI) score is able to predict the presence of PH. The APRI score has a similar diagnostic accuracy to combination index.