Franck M, Thon C, Schütte K, Malfertheiner P, Link A. Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function. World J Hepatol 2020; 12(11): 1031-1045 [PMID: 33312427 DOI: 10.4254/wjh.v12.i11.1031]
Corresponding Author of This Article
Alexander Link, MD, PhD, Academic Research, Associate Professor, Doctor, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, Germany. alexander.link@med.ovgu.de
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Nov 27, 2020; 12(11): 1031-1045 Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.1031
Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function
Martin Franck, Cosima Thon, Kerstin Schütte, Peter Malfertheiner, Alexander Link
Martin Franck, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany
Martin Franck, Cosima Thon, Kerstin Schütte, Peter Malfertheiner, Alexander Link, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg 39120, Germany
Kerstin Schütte, Department of Internal Medicine and Gastroenterology, Niels-Stensen-Kliniken Marienhospital, Osnabrück 49074, Germany
Author contributions: Franck M performed the experiments; Schütte K and Malfertheiner P provided the clinical material; Franck M, Thon C, and Link A carried out the analysis and interpretation of the data and drafting of the manuscript; Link A created the study concept and design and is the guarantor of the study; All authors edited and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the ethical board of the Otto-von-Guericke University (Study number 99/10).
Informed consent statement: The study was performed according to the principle of the Declaration of Helsinki. The study was approved by Institutional Review Board of Otto-von-Guericke University Magdeburg No. 99/10. All patients provided written informed consent.
Conflict-of-interest statement: Authors declare that they have no potential conflicts of interest.
Data sharing statement: Technical appendix and dataset available from the corresponding author: alexander.link@med.ovgu.de. Participants gave informed consent for data analysis and publication. Certain restriction may apply in accordance to patient´s consent.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alexander Link, MD, PhD, Academic Research, Associate Professor, Doctor, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, Germany. alexander.link@med.ovgu.de
Received: June 11, 2020 Peer-review started: June 12, 2020 First decision: July 30, 2020 Revised: August 15, 2020 Accepted: September 18, 2020 Article in press: September 18, 2020 Published online: November 27, 2020 Processing time: 165 Days and 3.8 Hours
Core Tip
Core Tip: In our previous work, we identified renal function, hemoglobin, and liver injury as potential factors that may impact circulating microRNA expression. miR-21-5p is the most frequently deregulated miRNA in various types of cancer. Several reports have proposed miR-21-5p as a prognostic biomarker in hepatocellular carcinoma. In this study, serum miR-21-5p values were not associated with prognosis of hepatocellular carcinoma in a European cohort of patients with predominantly alcohol-related liver injury. In a similar fashion as previously reported for miR-122-5p, changes in circulating miR-21-5p level correlated with renal function and liver injury. This observation shows that caution should be taken in interpreting circulating miR-21-5p level and its biomarker potential.
