Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2019; 11(2): 226-233
Published online Feb 27, 2019. doi: 10.4254/wjh.v11.i2.226
Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report
Katerina G Oikonomou, Dost Sarpel, Alexandra Abrams-Downey, Adnan Mubasher, Douglas T Dieterich
Katerina G Oikonomou, Dost Sarpel, Alexandra Abrams-Downey, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Mount Sinai St Luke’s-West, New York, NY 10025, United States
Adnan Mubasher, Department of Pathology, Icahn School of Medicine at Mount Sinai, Mount Sinai St Luke’s-West, New York, NY 10025, United States
Douglas T Dieterich, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Author contributions: Oikonomou KG manuscript preparation, clinical data collection and literature search and review; Sarpel D clinical data and literature review, critical review of the manuscript, clinical images preparation; Abrams-Downey A clinical data and literature review, critical review of the manuscript, clinical images preparation; Mubasher A pathology slides review and histologic description of the biopsy samples, pathology images/photomicroscopy preparation; Dieterich DT critical review of manuscript, clinical data and literature review.
Informed consent statement: Consent was obtained from patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Katerina G Oikonomou, MD, PhD, Academic Fellow, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Mount Sinai St Luke’s-West, 1111 Amsterdam Avenue, S and R 13, New York, NY 10025, United States. katerina.oikonomou@mountsinai.org
Telephone: +1-212-5232525 Fax: +1-212-5233931
Received: October 16, 2018
Peer-review started: October 16, 2018
First decision: November 15, 2018
Revised: December 13, 2018
Accepted: January 9, 2019
Article in press: January 9, 2019
Published online: February 27, 2019
Processing time: 133 Days and 19.1 Hours
Core Tip

Core tip: Necrolytic acral erythema (NAE) is a rare dermatological entity associated with hepatitis C virus (HCV) and zinc deficiency. Aim of the case report is to describe the occurrence of NAE in a human immunodeficiency virus/HCV coinfected patient, elucidate the clinical characteristics, pathophysiologic mechanisms and increase clinician awareness about diagnosis and management.