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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2019; 11(2): 208-216
Published online Feb 27, 2019. doi: 10.4254/wjh.v11.i2.208
Published online Feb 27, 2019. doi: 10.4254/wjh.v11.i2.208
Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation
Nicole D Triggs, Stacey Beer, Ryan W Himes, Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, TX 77030, United States
Sonam Mokha, College of Arts and Sciences, Washington University in St. Louis, St. Louis, MO 63130, United States
Kat Hosek, Outcomes and Impact Service, Texas Children’s Hospital, Houston, TX 77030, United States
Danielle Guffey, Charles G Minard, Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX 77030, United States
Flor M Munoz, Department of Pediatrics, Section of Infectious Disease, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Triggs ND, Beer S and Himes RW contributed to research design; Triggs ND, Beer S, Mokha S, Hosek K, Guffey D, Minard CG, Munoz FM and Himes RW contributed to acquisition and analysis of data, drafting and/or critical revision of manuscript; all authors approval of final version of manuscript.
Institutional review board statement: This study was approved by the Baylor College of Medicine Institutional Review Board and granted waiver of informed consent.
Informed consent statement: The Baylor College of Medicine Institutional Review Board granted waiver of informed consent for this project.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ryan W Himes, MD, Assistant Professor, Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, 6701 Fannin St, MWT 1010, Houston, TX 77030, United States. rwhimes@texaschildrens.org
Telephone: +1-832-8221050 Fax: +1-832-8253633
Received: November 14, 2018
Peer-review started: November 15, 2018
First decision: December 21, 2018
Revised: January 15, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 27, 2019
Processing time: 104 Days and 21.3 Hours
Peer-review started: November 15, 2018
First decision: December 21, 2018
Revised: January 15, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 27, 2019
Processing time: 104 Days and 21.3 Hours
Core Tip
Core tip: Rates of central line-associated bloodstream infection (CLABSI) are high among children with biliary atresia listed for liver transplantation. While most CLABSI represented enteric flora, Candida was isolated in 21% of events, suggesting that it may be appropriate to consider the use of antifungals in this population when empiric therapy doesn’t lead to expected clinical improvement. Since no factors we tested appeared to predict CLABSI, we propose that prevention efforts should be focused on universal and meticulous application of known CLABSI-reducing strategies, such as line insertion bundles.