Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2019; 11(12): 752-760
Published online Dec 27, 2019. doi: 10.4254/wjh.v11.i12.752
Post-infantile giant cell hepatitis: A single center’s experience over 25 years
Bassem Matta, Ricardo Cabello, Mordechai Rabinovitz, Marta Minervini, Shahid Malik
Bassem Matta, Mordechai Rabinovitz, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA 15213, United States
Ricardo Cabello, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Marta Minervini, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, United States
Shahid Malik, Department of Medicine, University of Pittsburgh, Division of Gastroenterology Hepatology and Nutrition, Pittsburgh, PA 15213, United States
Author contributions: Matta B and Malik SM designed the research study, obtained and analyzed data and wrote manuscript; Cabello R, Rabinovitz M and Minervini M contributed with data interpretation and critical review of manuscript for intellectual content; All authors have read and approve the final manuscript.
Institutional review board statement: This study was reviewed and approved by the University of Pittsburgh Medical Center Institution Review Board PRO12030073.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There were no conflict of interests to disclose.
Data sharing statement: All data requests should be submitted to the corresponding author for consideration. Access to anonymized data may be granted following review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Shahid Malik, MD, Department of Medicine, University of Pittsburgh, Division of Gastroenterology, Hepatology and Nutrition, 3471 5th Ave 916 Lillian Kaufman Building, Pittsburgh, PA 15213, United States.
Telephone: +1-412-6474932 Fax: +1-412-6479268
Received: May 15, 2019
Peer-review started: May 17, 2019
First decision: July 4, 2019
Revised: September 9, 2019
Accepted: October 18, 2019
Article in press: October 18, 2019
Published online: December 27, 2019
Core Tip

Core tip: Post-infantile giant cell hepatitis is a rare disorder and very poorly defined in the literature. Our study aimed to present our center’s experience in an attempt to shed more light about the predisposing factors, outcomes and efficacy of proposed therapeutic interventions for post-infantile giant cell hepatitis.