Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2019; 11(1): 127-132
Published online Jan 27, 2019. doi: 10.4254/wjh.v11.i1.127
Non-uremic calciphylaxis associated with alcoholic hepatitis: A case report
Yasser M Sammour, Haitham M Saleh, Mohamed M Gad, Brayden Healey, Melissa Piliang
Yasser M Sammour, Mohamed M Gad, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, United States
Haitham M Saleh, Department of Dermatology, Ain Shams University, Cairo 11566, Egypt
Brayden Healey, College of Osteopathic Medicine of the Pacific-Northwest, Western University of Health Sciences, Lebanon, OR 97355, United States
Melissa Piliang, Department of Dermatology, Cleveland Clinic, Cleveland 44195, OH, United States
Author contributions: Sammour YM designed the research and collected the patient’s clinical data; Piliang M provided the patient’s histopathological information; Sammour YM, Saleh HM, Gad MM, Healey B, Piliang M analyzed the data and wrote the paper.
Informed consent statement: A phone consent was obtained from the patient’s husband after the patient passed away. The phone conversation was documented in the patient’s electronic medical record.
Conflict-of-interest statement: No conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yasser M Sammour, MD, Research Fellow, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Ave, J2-606, Cleveland, OH 44195, United States. sammouy@ccf.org
Telephone: +1-216-3346144
Received: September 4, 2018
Peer-review started: September 4, 2018
First decision: October 15, 2018
Revised: December 2, 2018
Accepted: January 3, 2019
Article in press: January 4, 2019
Published online: January 27, 2019
Processing time: 145 Days and 11.1 Hours
Core Tip

Core tip: In this case report, we present a patient with alcoholic liver disease and low levels of Protein C who developed calciphylaxis and died shortly after due to complications. The pathogenesis is not completely understood but the disruption of calcium-phosphate-byproduct has been implicated to play a role in the disease process. Liver dysfunction can lead to low levels of coagulation inhibitors specifically Protein C and Protein S. The aim of the medical treatment is to lower the calcium-phosphate-byproduct and decrease the vascular calcification. The use of surgical wound debridement is less established.