Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2018; 10(9): 558-570
Published online Sep 27, 2018. doi: 10.4254/wjh.v10.i9.558
Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma
Evangelista Sagnelli, Nicoletta Potenza, Lorenzo Onorato, Caterina Sagnelli, Nicola Coppola, Aniello Russo
Evangelista Sagnelli, Lorenzo Onorato, Caterina Sagnelli, Nicola Coppola, Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Naples 80135, Italy
Nicoletta Potenza, Aniello Russo, DISTABIF, University of Campania “Luigi Vanvitelli”, Naples 80100, Italy
Author contributions: All authors contributed equally to this paper with the conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Evangelista Sagnelli, MD, Full Professor, Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Via: L. Armanni 5, Naples 80135, Italy. evangelista.sagnelli@unicampania.it
Telephone: +39-81-5666719 Fax: +39-81-5666207
Received: March 25, 2018
Peer-review started: March 28, 2018
First decision: April 19, 2018
Revised: April 24, 2018
Accepted: May 30, 2018
Article in press: May 30, 2018
Published online: September 27, 2018
Processing time: 183 Days and 19.2 Hours
Core Tip

Core tip: This review article will focus on the emerging puzzle of hepatitis B virus (HBV)-hepatocyte interaction via miRNAs, indirectly or directly modulating HBV replication and pathogenesis, and thus on the role of microRNAs in the natural history of HBV infection. We evaluated the literature on their possible future role as a biomarker in the management of patients with HBV-related disease and as therapeutic targets.