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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2018; 10(7): 474-478
Published online Jul 27, 2018. doi: 10.4254/wjh.v10.i7.474
Published online Jul 27, 2018. doi: 10.4254/wjh.v10.i7.474
Associations between nonalcoholic fatty liver disease and ischemic stroke
Stelina Alkagiet, Achilleas Papagiannis, Konstantinos Tziomalos, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki 54636, Greece
Author contributions: Alkagiet S and Papagiannis A drafted the review; Tziomalos K critically revised the draft.
Conflict-of-interest statement: All authors declare no conflict of interest related to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Konstantinos Tziomalos, MD, PhD, Assistant Professor, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, Thessaloniki 54636, Greece. ktziomalos@yahoo.com
Telephone: +30-2310-994621 Fax: +30-2310-994773
Received: March 27, 2018
Peer-review started: March 28, 2018
First decision: April 13, 2018
Revised: April 22, 2018
Accepted: May 30, 2018
Article in press: May 31, 2018
Published online: July 27, 2018
Peer-review started: March 28, 2018
First decision: April 13, 2018
Revised: April 22, 2018
Accepted: May 30, 2018
Article in press: May 31, 2018
Published online: July 27, 2018
Core Tip
Core tip: Accumulating data suggest that nonalcoholic fatty liver disease (NAFLD) is independently associated with increased risk for ischemic stroke, a leading cause of mortality and long-term disability worldwide. Moreover, emerging evidence shows that patients with NAFLD experience more severe ischemic stroke and have more unfavorable prognosis after an acute ischemic stroke in terms of functional dependency and short- and long-term mortality.