Vishwakarma SK, Lakkireddy C, Bardia A, Paspala SAB, Tripura C, Habeeb MA, Khan AA. Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases. World J Hepatol 2018; 10(11): 822-836 [PMID: 30533183 DOI: 10.4254/wjh.v10.i11.822]
Corresponding Author of This Article
Aleem Ahmed Khan, PhD, Associate Professor, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Nov 27, 2018; 10(11): 822-836 Published online Nov 27, 2018. doi: 10.4254/wjh.v10.i11.822
Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases
Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Avinash Bardia, Syed Ameer Basha Paspala, Md Aejaz Habeeb, Aleem Ahmed Khan, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India
Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Avinash Bardia, Syed Ameer Basha Paspala, Md Aejaz Habeeb, Aleem Ahmed Khan, Dr Habeebullah Life Sciences, Attapur, Hyderabad 500058, Telangana, India
Chaturvedula Tripura, CSIR-Centre for Cellular and Molecular Biology, Habsiguda, Hyderabad 500007, Telangana, India
Author contributions: Vishwakarma SK and Khan AA conceptualized the study; Vishwakarma SK, Lakkireddy C, Bardia A, Tripura C and Khan AA wrote the manuscript; Vishwakarma SK, Lakkireddy C and Bardia A performed literature survey; Tripura C, Paspala SAB, Habeeb MA and Khan AA gave his basic and clinical inputs during manuscript draft preparation; Vishwakarma SK, Paspala SAB, Habeeb MA and Khan AA edited the manuscript; Vishwakarma SK and Lakkireddy C formatted the manuscript.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Aleem Ahmed Khan, PhD, Associate Professor, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com
Telephone: +91-40-24342954 Fax: +91-40-24342954
Received: July 10, 2018 Peer-review started: July 10, 2018 First decision: August 20, 2018 Revised: August 24, 2018 Accepted: October 11, 2018 Article in press: October 11, 2018 Published online: November 27, 2018 Processing time: 141 Days and 5.6 Hours
Core Tip
Core tip: The concept of bioengineering functional humanized neo-organs relies on finding more appropriate immunologically tolerable transplantation site. We have experienced omentum as more appropriate ectopic site with excellent properties of angiogenesis, regeneration, fibrotic reconstruction, and immunological compatibility which together endorse vascularisation, promote tissue healing, and minimize rejection of foreign body. However, regeneration of liver tissue in omentum is still unknown. Despite the amazing breakthroughs in the bioengineered organs, there is much work left to do. The approach described herein harbours enormous potential to overcome the limitations of organ transplantation and may support failing liver through ectopic transplantation as secondary organ.
