Papadopoulos VP, Mimidis K. Corrected QT interval in cirrhosis: A systematic review and meta-analysis. World J Hepatol 2023; 15(9): 1060-1083 [PMID: 37900213 DOI: 10.4254/wjh.v15.i9.1060]
Corresponding Author of This Article
Vasileios Periklis Papadopoulos, MD, MSc, PhD, Consultant Physician-Scientist, Research Fellow, Dialysis, AKESIOS Dialysis Center, Vaniano, Xanthi 67150, Greece. vaspapmd@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Vasileios Periklis Papadopoulos, Dialysis, AKESIOS Dialysis Center, Xanthi 67150, Greece
Konstantinos Mimidis, First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis 68100, Greece
Author contributions: Papadopoulos VP contributed to design of the study; Papadopoulos VP and Mimidis K contributed to conception of the study, acquisition, analysis and interpretation of the data, and drafting of the manuscript; and all authors gave final approval of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: July 16, 2023 Peer-review started: July 16, 2023 First decision: August 4, 2023 Revised: August 13, 2023 Accepted: August 29, 2023 Article in press: August 29, 2023 Published online: September 27, 2023
ARTICLE HIGHLIGHTS
Research background
The effects of sex, age, severity, and etiology, as well as the role of treatment, acute illness, and liver transplantation (Tx) are largely unknown regarding corrected QT (QTc) in cirrhosis.
Research motivation
It is unknown whether QTc is prolonged in patients with cirrhosis and whether QTc is affected by factors such as sex, age, severity, etiology, regimens, acute illness, and liver Tx.
Research objectives
To investigate QTc clinical usefulness in cirrhosis.
Research methods
Seventy-three studies were considered eligible, as identified by application of the search protocol “{[QTc] OR [QT interval] OR [QT-interval] OR [Q-T syndrome]} AND {[cirrhosis] OR [Child-Pugh] OR [MELD]}” in PubMed, EMBASE, and Google Scholar databases.
Research results
QTc was prolonged in patients with cirrhosis independent of sex and age (444.8 ± 4.4 ms). QTc correlated with Child-Pugh stage and model for end-stage liver disease score. QTc improved after liver Tx.
Research conclusions
QT prolongation in cirrhosis is independent of sex and age, is aggravated in severe cases, and benefited by liver Tx.
Research perspectives
QTc interval could be further evaluated as a tool in the assessment of liver cirrhosis by clinicians.
