Lai Y, Lee JC, Hung HC, Wang YC, Cheng CH, Wu TH, Lee CF, Wu TJ, Chou HS, Chan KM, Kao CY, Lee WC. Modified preoperative score to predict disease-free survival for hepatocellular carcinoma patients with surgical resections. World J Hepatol 2022; 14(9): 1778-1789 [PMID: 36185727 DOI: 10.4254/wjh.v14.i9.1778]
Corresponding Author of This Article
Wei-Chen Lee, MD, Professor, Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, No. 5 Fu-Hsing Street, Kwei-Shan, Taoyuan 333, Taiwan. weichen@cgmh.org.tw
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yin Lai, Jin-Chiao Lee, Hao-Chien Hung, Yu-Chao Wang, Chih-Hsien Cheng, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Wei-Chen Lee, Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 333, Taiwan
Chen-Yao Kao, Department of Special Education, National University of Tainan, Tainan 700, Taiwan
Author contributions: Lai Y designed and performed the research and wrote the paper; Hung HC and Lee JC contributed to the analysis; Wang YC, Cheng CH, Wu TH, Lee CF, Wu TJ, Chou HS, and Chan KM provided clinical advice; Kao CY contributed to the final manuscript; Lee WC supervised the report.
Institutional review board statement: This study was approved by the local ethics committee of Chang Gung Memorial Hospital, No. 104-3900B.
Informed consent statement: Because of retrospective study, signed informed consent form is not needed. However, Chang-Gung Memorial Hospital has given permission to conduct this study.
Conflict-of-interest statement: The authors declare that there are no conflict of interests.
Data sharing statement: The data that support the findings of this study are available from the corresponding author, Lee WC, upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Chen Lee, MD, Professor, Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, No. 5 Fu-Hsing Street, Kwei-Shan, Taoyuan 333, Taiwan. weichen@cgmh.org.tw
Received: January 12, 2022 Peer-review started: January 12, 2022 First decision: April 16, 2022 Revised: April 30, 2022 Accepted: August 22, 2022 Article in press: August 22, 2022 Published online: September 27, 2022 Processing time: 253 Days and 9.8 Hours
ARTICLE HIGHLIGHTS
Research background
No preoperative prognostic models specific to hepatocellular carcinoma patients receiving surgical resection have been considered strong and convincing enough for survival prediction.
Research motivation
We previously derived a nomogram but aimed to simplify the score and compare it with other scoring systems.
Research objectives
To develop a simple preoperative score with satisfactory predictive power compared to postoperative scoring systems.
Research methods
Significant risk factors were identified using a multivariate Cox proportional hazards model. The homogeneity, Harrell’s C-index, and Akaike information criterion of the different scoring systems were compared.
Research results
Five risk factors were identified, and patients were divided into three risk groups. The C-index of our preoperative score was 0.617, which is equal to the value of the AJCC 8th edition.
Research conclusions
A modified score was established for survival prediction, and patients were divided into risk groups for preoperative treatment planning.
Research perspectives
Specific treatment or monitoring plan modifications for each risk group should be studied and potential correlation with survival benefit should be investigated.
