Yoshida N, Yamazaki S, Masamichi M, Okamura Y, Takayama T. Prospective validation to prevent symptomatic portal vein thrombosis after liver resection. World J Hepatol 2022; 14(5): 1016-1024 [PMID: 35721290 DOI: 10.4254/wjh.v14.i5.1016]
Corresponding Author of This Article
Shintaro Yamazaki, PhD, Associate Professor, Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchi kami-mahi Itabashi-ku, Tokyo 1738610, Japan. yamazaki-nmed@umin.ac.jp
Research Domain of This Article
Surgery
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nao Yoshida, Shintaro Yamazaki, Moriguchi Masamichi, Yukiyasu Okamura, Tadatoshi Takayama, Department of Digestive Surgery, Nihon University School of Medicine, Tokyo 1738610, Japan
Author contributions: Yoshida N collected the patient’s data; Yamazaki S designed this study; Masamichi M contributed to the proofreading of manuscript; Okamura Y and Takayama T supervised the writing of the manuscript.
Institutional review board statement: The ethics committee of Nihon University School of Medicine approved this clinical study.
Clinical trial registration statement: This study was registered in the UMIN Clinical Trials Registry under entry number UMIN000047362.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Authors have no conflict-of-interest of this study.
Data sharing statement: Author can provide any data of this study.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shintaro Yamazaki, PhD, Associate Professor, Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchi kami-mahi Itabashi-ku, Tokyo 1738610, Japan. yamazaki-nmed@umin.ac.jp
Received: March 26, 2021 Peer-review started: March 26, 2021 First decision: August 18, 2021 Revised: September 17, 2021 Accepted: May 8, 2022 Article in press: May 8, 2022 Published online: May 27, 2022
ARTICLE HIGHLIGHTS
Research background
Portal vein thrombus (PVT) is one of the potentially lethal complication after liver resection; however, its etiology and the way for immediate treatment is unsettled.
Research motivation
Based on our experience, we tried to resolve hepatic failure due to huge PVT.
Research objectives
The study was conducted in patients who underwent open liver resection for cancer in our institution.
Research methods
Retrospective but retrospectively collected cohort.
Research results
In a total of 235 patients, 8 had major PVT. We successfully treated the patients with anticoagulant therapy without adverse events. No hepatic failure observed through this study.
Research conclusions
Performing enhanced computed tomography (CT) on post-operative day 1 is an effective option to find a thrombi at the portal vein close to the surgical site.
Research perspectives
The early detection of PVT by enhanced CT is a promising way to avoid hepatic failure after liver resection.
