Dar SH, Rahim M, Hosseini DK, Sarfraz K. Impact of liver cirrhosis on ST-elevation myocardial infarction related shock and interventional management, a nationwide analysis. World J Hepatol 2022; 14(4): 766-777 [PMID: 35646267 DOI: 10.4254/wjh.v14.i4.766]
Corresponding Author of This Article
Sophia Haroon Dar, MD, Doctor, Internal Medicine, Hackensack University Medical Center, 30 Prospect Avenue Department of Internal Medicine Hackensack University Medical Center Hackensack NJ, 70601, Hackensack, NJ 07601, United States. sophia.dar@hmhn.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Apr 27, 2022; 14(4): 766-777 Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.766
Impact of liver cirrhosis on ST-elevation myocardial infarction related shock and interventional management, a nationwide analysis
Sophia Haroon Dar, Mehek Rahim, Davood K Hosseini, Khurram Sarfraz
Sophia Haroon Dar, Mehek Rahim, Davood K Hosseini, Khurram Sarfraz, Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, United States
Author contributions: Dar SH decided topic, designed study, completed the analysis, wrote, edited, and finalized paper; Rahim M participated in editing and finalizing the paper; Hoesseini DK and Sarfraz K participated in writing the initial draft.
Institutional review board statement: This is a retrospective review on a national database and did not require IRB approval.
Informed consent statement: This project was done on a large database national inpatient sample and did not require individual patient consent as it is a publicly available database.
Conflict-of-interest statement: There are no known conflicts of interest.
Data sharing statement: No individual patient identifiers are present in the national database. Therefore, no individual can be traced.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sophia Haroon Dar, MD, Doctor, Internal Medicine, Hackensack University Medical Center, 30 Prospect Avenue Department of Internal Medicine Hackensack University Medical Center Hackensack NJ, 70601, Hackensack, NJ 07601, United States. sophia.dar@hmhn.org
Received: November 8, 2021 Peer-review started: November 8, 2021 First decision: December 12, 2021 Revised: January 4, 2022 Accepted: March 7, 2022 Article in press: March 7, 2022 Published online: April 27, 2022
ARTICLE HIGHLIGHTS
Research background
ST-Elevation myocardial infarction (STEMI) remains a significant cause of morbidity and mortality globally. A particularly susceptible population are patients with liver cirrhosis.
Research motivation
This study aims to find what factors predicted morbidity and mortality in patients with liver cirrhosis that may need to undergo interventional management for STEMI related cardiogenic shock.
Research objectives
We aim to identify predictors of morbidity and mortality in patient with liver cirrhosis that undergo interventional management for STEMI related cardiogenic shock. We aim to find the effect of liver cirrhosis on mortality, length of stay, and hospital costs in patients with STEMI related cardiogenic shock.
Research methods
We conducted a retrospective review on the national inpatient sample 2017. Using the student t-test and propensity-matched multivariate logistic regression, we were able to find the P value and odds of mortality.
Research results
We find that patients with liver cirrhosis have significantly higher morbidity and mortality rates than those without liver cirrhosis. They are also susceptible to adverse outcomes when undergoing interventional management.
Research conclusions
Physicians must optimize patients with liver cirrhosis before any interventional procedure. Patients with mild cirrhosis seemed to have better outcomes than patients with moderate-severe liver cirrhosis.
Research perspectives
This research will help build the framework for future studies to study this topic further. The goal would be to identify a scoring system that would allow physicians to ascertain which patients would be safely able to undergo interventional management and which would not. As of now, it is mostly under clinical judgment.
