Kaida T, Hayashi H, Sato H, Kinoshita S, Matsumoto T, Shiraishi Y, Kitano Y, Higashi T, Imai K, Yamashita YI, Baba H. Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1. World J Hepatol 2022; 14(1): 234-243 [PMID: 35126851 DOI: 10.4254/wjh.v14.i1.234]
Corresponding Author of This Article
Hiromitsu Hayashi, FACS, MD, PhD, Assistant Professor, Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. hhayasi@kumamoto-u.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Takayoshi Kaida, Hiromitsu Hayashi, Hiroki Sato, Shotaro Kinoshita, Takashi Matsumoto, Yuta Shiraishi, Yuki Kitano, Takaaki Higashi, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba, Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
Author contributions: Kaida T and Hayashi H identified the concept and wrote the draft of the article; Sato H, Kinoshita S, Matsumoto T, Siraishi Y, Kitano Y, Higashi T, and Imai K actually treated the patient and collected data; Yamashita Y and Baba Hsupervised article preparation.
Institutional review board statement: This study was retrospective, non-interventional, which approved by the institutional ethics committee of Kumamoto University Hospital (approval No.2052) and was performed in accordance with the Helsinki Declaration of 1975.
Informed consent statement: Written informed consent was obtained from all patients.
Conflict-of-interest statement: We declare that we have no competing interests.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiromitsu Hayashi, FACS, MD, PhD, Assistant Professor, Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. hhayasi@kumamoto-u.ac.jp
Received: March 27, 2021 Peer-review started: March 27, 2021 First decision: June 15, 2021 Revised: June 23, 2021 Accepted: December 11, 2021 Article in press: December 11, 2021 Published online: January 27, 2022 Processing time: 299 Days and 20.5 Hours
ARTICLE HIGHLIGHTS
Research background
There are few reports that have scientifically verified whether laparoscopic surgery is truly minimally invasive in liver resection.
Research motivation
Evaluation of minimally invasive laparoscopic surgery will also be important when robot-assisted surgery becomes more widespread in the future. There are many unclear points, such as whether invasion reflects skin incision size or organ invasion.
Research objectives
We aimed to verify whether the laparoscopic technique contributes to minimally invasive procedures in surgery using biomarkers of interleukin-6 (IL-6) and thrombospondin-1 (TSP-1).
Research methods
This study is a retrospective study. Serum IL-6 and TSP-1 were measured and analyzed by ELISA using blood samples taken before and after surgery. We also evaluated the relationship between the operative approach, the size of the skin incision and the presence of liver mobilization.
Research results
This study demonstrated that laparoscopic liver resection is likely to be scientifically less invasive than open liver resection. The lower IL-6 Level was significantly related to the operative methods. The limitation of this study is that the number of cases is small, so further accumulation and analysis is needed in the future.
Research conclusions
In patients who undergo liver resection, laparoscopic approach that is less invasive than open approach is preferred whenever possible.
Research perspectives
Studies conducted in the future should focus on evaluating whether biomarker such as IL-6 affected not only short-term outcomes but also long-term outcomes and how several biomarker change with robot-assisted techniques.
