Alukal JJ, Zhang T, Thuluvath PJ. Mortality and health care burden of Budd Chiari syndrome in the United States: A nationwide analysis (1998-2017). World J Hepatol 2021; 13(6): 686-698 [PMID: 34239703 DOI: 10.4254/wjh.v13.i6.686]
Corresponding Author of This Article
Paul Joseph Thuluvath, FAASLD, AGAF, FACG, FRCP, MBBS, MD, Director, Professor, Institute of Digestive Health and Liver Diseases, Mercy Medical Center, 301 Saint Paul Place, Baltimore, MD 21202, United States. thuluvath@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jun 27, 2021; 13(6): 686-698 Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.686
Mortality and health care burden of Budd Chiari syndrome in the United States: A nationwide analysis (1998-2017)
Joseph J Alukal, Talan Zhang, Paul Joseph Thuluvath
Joseph J Alukal, Talan Zhang, Paul Joseph Thuluvath, Institute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD 21202, United States
Paul Joseph Thuluvath, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, United States
Author contributions: Alukal JJ and Thuluvath PJ contributed to the conception and design, the acquisition, analysis, interpretation of the data, the drafting of the article or critical revision for important intellectual content; Zhang T did the statistical analysis, and all authors approved the final version, and agree to be accountable for all aspects of the work.
Institutional review board statement: Since the data used for this this study were de-identified, IRB approval was not required as per local hospital IRB requirements.
Informed consent statement: Being a de-identified database study, consent form is not applicable.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: NIS datasets are available to everyone at a nominal fee.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Paul Joseph Thuluvath, FAASLD, AGAF, FACG, FRCP, MBBS, MD, Director, Professor, Institute of Digestive Health and Liver Diseases, Mercy Medical Center, 301 Saint Paul Place, Baltimore, MD 21202, United States. thuluvath@gmail.com
Received: February 18, 2021 Peer-review started: February 18, 2021 First decision: March 16, 2021 Revised: March 27, 2021 Accepted: May 20, 2021 Article in press: May 20, 2021 Published online: June 27, 2021 Processing time: 124 Days and 3.3 Hours
ARTICLE HIGHLIGHTS
Research background
The Budd Chiari syndrome (BCS) is a rare disorder that results from partial or complete obstruction of the hepatic venous outflow in the absence of right heart failure.
Research motivation
There is a paucity of data on the in-hospital mortality of BCS as well its economic impact on the United States health care system.
Research objectives
This study aimed to evaluate trends in mortality, length of hospital stays and resource utilization among inpatients with BCS.
Research methods
Retrospective study where data were extracted from the National Inpatient Sample (NIS) from 1998 to 2017. To make inferences regarding the national estimates for the total number of BCS discharges across the study period, sample weights were applied to each admission per recommendations from the NIS.
Research results
During the study period, there were 3591 (8.73%) in-patient deaths. The overall in-hospital mortality rate among BCS patients decreased from 18% in 1998 to 8% in 2017; the mortality decreased by 4.41% every year. The average of length of stay was 8.8 d and it consistently decreased by 2.04% from 12.7 d in 1998 to 7.6 d in 2017.The average total charges during the time period was $94440 and the annual percentage change increased by 1.15%
Research conclusions
The in-hospital mortality rate for patients admitted with BCS in the United States has reduced between 1998 and 2017 while total charges continued to increase.
Research perspectives
Using a large national database, we analyzed the mortality and socioeconomic impact of BCS hospitalizations in the United States with a high degree of granularity.
