Published online Dec 28, 2016. doi: 10.4254/wjh.v8.i36.1593
Peer-review started: April 7, 2016
First decision: June 7, 2016
Revised: September 9, 2016
Accepted: November 1, 2016
Article in press: November 2, 2016
Published online: December 28, 2016
The pathway from clinical suspicion to establishing the diagnosis of biliary atresia in a child with jaundice is a daunting task. However, investigations available help to point towards the correct diagnosis in reasonable time frame. Imaging by Sonography has identified several parameters which can be of utility in the diagnostic work up. Comparison of Sonography with imaging by Nuclear medicine can bring out the significant differences and also help in appropriate imaging. The battery of Biochemical tests, available currently, enable better understanding of the line-up of investigations in a given child with neonatal cholestasis. Management protocols enable standardized care with optimal outcome. The place of surgical management in biliary atresia is undisputed, although Kasai procedure and primary liver transplantation have been pitted against each other. This article functions as a platform to bring forth the various dimensions of biliary atresia.
Core tip: The etiology of biliary atresia is intriguing with a myriad of diagnostics available to work up a child with neonatal jaundice. This article attempts to review the pathogenesis, evaluation, management and outcome for current update of biliary atresia.