Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 28, 2016; 8(30): 1251-1261
Published online Oct 28, 2016. doi: 10.4254/wjh.v8.i30.1251
Insights for hepatitis C virus related hepatocellular carcinoma genetic biomarkers: Early diagnosis and therapeutic intervention
Wafaa M Ezzat, Khalda Sayed Amr
Wafaa M Ezzat, Department of Internal Medicine, National Research Center, Cairo 12311, Egypt
Khalda Sayed Amr, Department of Medical Molecular Genetics, National Research Center, Cairo 12311, Egypt
Author contributions: Both authors equally in collecting data and writing the article.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wafaa M Ezzat, MD, Professor of Gastroenterology and Hepatology, Department of Internal Medicine, National Research Center, Elbohoosst, Dokki, Cairo 12311, Egypt. wafaa_3t@yahoo.com
Telephone: +20-10-06063558
Received: March 28, 2016
Peer-review started: March 31, 2016
First decision: June 12, 2016
Revised: July 25, 2016
Accepted: September 6, 2016
Article in press: September 8, 2016
Published online: October 28, 2016
Processing time: 210 Days and 19.2 Hours
Abstract

The current review explores the role of emerging molecular contributing factors in liver carcinogenesis on top of hepatitis C virus (HCV). Here we will try to discuss the role genetic and epigenetic factors in pathogenesis of hepatocellular carcinoma. Understanding the role of these factors will help in discovering the mystery of liver carcinogenesis on top of chronic HCV infection. Moreover, use of the studied molecular factors will provide the hepatologists with tailored diagnostic promising biomarkers and flatten the way for establishment of emerging molecular treatment based on exploring the molecular subscription of this aggressive liver cancer.

Keywords: Hepatitis C virus; Hepatocellular carcinoma; Genetic; Epigenetic; Diagnosis

Core tip: It was evident that pathogenesis of hepatocellular carcinoma (HCC) among cases with hepatitis C virus (HCV) infection results from interaction between viral factors and host factors. The host factors include genetic and immunologic factors. Identifying the emerging genetic factors which are contributing in pathogenesis of liver cancer is considered as revolution in research fields of genetics and oncology. Detection of early promising diagnostic biomarkers and development of specific therapy for HCV related HCC is the hope of most researchers in the related fields.