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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 8, 2016; 8(1): 1-8
Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.1
Metabonomic window into hepatitis B virus-related hepatic diseases
Qiang Hou, Zhi-Jun Duan
Qiang Hou, Zhi-Jun Duan, Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Author contributions: Hou Q searched the literature and drafted the review; Duan ZJ supervised the review.
Supported by Liaoning Natural Science Foundation of China, No. 2013B003.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Jun Duan, Professor, Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Zhongshan Road, Xigang District, Dalian 116011, Liaoning Province, China. cathydoctor@sina.com
Telephone: +86-411-83635963
Received: April 29, 2015
Peer-review started: May 7, 2015
First decision: August 11, 2015
Revised: November 23, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: January 8, 2016
Processing time: 252 Days and 13.7 Hours
Abstract

Metabonomics has recently been widely used to discover the pathogenesis and find potential metabolic markers with high sensitivity and specificity. Furthermore, it develops new diagnosis and treatment methods, increases early phase diagnosis rates of certain diseases and provides a new basis for targeted therapy. This review mainly analyzes the research progress of the metabonomics of hepatitis B virus (HBV)-related hepatic diseases, hoping to discover some potential metabolic markers for identification of HBV-related hepatic diseases from other etiologies and for HBV-related hepatitis, liver cirrhosis and hepatocellular carcinoma. This can contribute to early discovery, diagnosis and treatment, eventually increasing the survival rate of HBV-related hepatic diseases.

Keywords: Metabonomics; Hepatitis B virus-related hepatic diseases; Hepatitis B; Hepatitis B virus-related liver cirrhosis; Hepatitis B virus-related hepatocellular carcinoma

Core tip: This review mainly analyzes the research progress of the metabonomics of hepatitis B virus (HBV)-related hepatic diseases, hoping to discover some potential metabolic markers which can distinguish HBV-related hepatic diseases from other etiologies and discover potential metabolic markers of HBV-related hepatitis, liver cirrhosis and hepatocellular carcinoma, which can contribute to early discovery, diagnosis and treatment.