Mohamed AA, Elbedewy TA, El-Serafy M, El-Toukhy N, Ahmed W, Ali El Din Z. Hepatitis C virus: A global view. World J Hepatol 2015; 7(26): 2676-2680 [PMID: 26609344 DOI: 10.4254/wjh.v7.i26.2676]
Corresponding Author of This Article
Dr. Amal Ahmed Mohamed, Consultant of Biochemistry and Molecular Biology, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Fom El-Khalig, Cairo 11796, Egypt. amalahmedhcp@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Nov 18, 2015; 7(26): 2676-2680 Published online Nov 18, 2015. doi: 10.4254/wjh.v7.i26.2676
Hepatitis C virus: A global view
Amal Ahmed Mohamed, Tamer A Elbedewy, Magdy El-Serafy, Naglaa El-Toukhy, Wesam Ahmed, Zaniab Ali El Din
Amal Ahmed Mohamed, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Cairo 11796, Egypt
Tamer A Elbedewy, Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta 31111, Egypt
Magdy El-Serafy, Tropical Department, National Hepatology and Tropical Medicine Institute; Cairo 11796, Egypt
Naglaa El-Toukhy, Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Benha University, Banha 13511, Egypt
Wesam Ahmed, Zaniab Ali El Din, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
Author contributions: All authors contributed equally to this work.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Amal Ahmed Mohamed, Consultant of Biochemistry and Molecular Biology, Biochemistry Department, National Hepatology and Tropical Medicine Institute, Fom El-Khalig, Cairo 11796, Egypt. amalahmedhcp@yahoo.com
Telephone: +20-12-24847367
Received: September 9, 2014 Peer-review started: September 9, 2014 First decision: September 28, 2014 Revised: July 29, 2015 Accepted: November 3, 2015 Article in press: November 4, 2015 Published online: November 18, 2015 Processing time: 434 Days and 23.1 Hours
Abstract
Hepatitis C virus (HCV) is a global challenge; 130-175 million are chronically infected. Over 350000 die each year from HCV. Chronic HCV is the primary cause of cirrhosis, hepatocellular carcinoma (HCC), and end-stage liver disease. Management of chronic HCV is aimed at preventing cirrhosis, reducing the risk of HCC, and treating extra hepatic complications. New treatments for chronic HCV has been devoted based on direct-acting antivirals, as pegylated interferon (peginterferon) is responsible for many side effects and limits treatment access. Sofosbuvir is the first compound to enter the market with Peginterferon-free combination regimens.
Core tip: Peginterferon is responsible for many side effects. Direct-acting antiviral drugs represent a breakthrough in hepatitis C virus (HCV) therapy. Sofosbuvir is the first compound to enter the market with Peginterferon-free combination regimens. The next few years are expected to introduce more new drugs in the market of HCV therapy with complete elimination of pegylated interferon and ribavirin combination therapy.
