Abbasoglu O. Role of liver resection in the management of multinodular hepatocellular carcinoma. World J Hepatol 2015; 7(20): 2237-2240 [PMID: 26380648 DOI: 10.4254/wjh.v7.i20.2237]
Corresponding Author of This Article
Dr. Osman Abbasoglu, Department of Surgery, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara 06100, Turkey. osmanabbasoglu@yahoo.com
Research Domain of This Article
Surgery
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Sep 18, 2015; 7(20): 2237-2240 Published online Sep 18, 2015. doi: 10.4254/wjh.v7.i20.2237
Role of liver resection in the management of multinodular hepatocellular carcinoma
Osman Abbasoglu
Osman Abbasoglu, Department of Surgery, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
Author contributions: Abbasoglu O performed the literature review and prepared the manuscript; Abbasoglu O solely contributed to this paper.
Conflict-of-interest statement: The author whose name is listed immediately below certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Osman Abbasoglu, Department of Surgery, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara 06100, Turkey. osmanabbasoglu@yahoo.com
Telephone: +90-532-3649039 Fax: +90-312-4262421
Received: May 14, 2015 Peer-review started: May 14, 2015 First decision: June 24, 2015 Revised: August 2, 2015 Accepted: September 1, 2015 Article in press: September 2, 2015 Published online: September 18, 2015 Processing time: 124 Days and 16.7 Hours
Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths worldwide. Various treatment modalities have been applied to HCC depending on the tumor load, functional capacity of the liver and the general condition of the patient. According to Barcelona Clinic Liver Cancer staging strategy and The American Association for the Study of Liver Disease guidelines, surgical resection is not advocated in the tretment of multinodular HCC. Despite this, many recent clinical studies show that, resection can achieve good results in patients with multinodular HCC and 5-year survival rate around 40% can be reached. If resection or transplantation is not performed, these patients are usually managed with palliative procedures such as transarterial chemoembolization, radioembolization and cytotoxic chemotherapy and 5-year survival of this group of patients will be extremely low. Although survival rates are lower and complications may be increased in this group of patients, liver resection can safely be performed in selected patients in experienced centers for the management of multinodular HCC.
Core tip: Liver resection is underutilized in the management of multinodular hepatocellular carcinoma. The presence of multiple nodules should not be considered as a contraindication for surgical resection. Acceptable 5-year survival rates can be achieved in selected patients.
