Published online Jul 8, 2015. doi: 10.4254/wjh.v7.i13.1788
Peer-review started: October 13, 2014
First decision: October 28, 2014
Revised: December 3, 2014
Accepted: May 5, 2015
Article in press: May 6, 2015
Published online: July 8, 2015
AIM: To review all of epidemiological aspects of non-alcoholic fatty liver disease (NAFLD) and also prevent this disease is examined.
METHODS: We conducted a systematic review according to the PRISMA guidelines. All searches for writing this review is based on the papers was found in PubMed (MEDLINE), Cochrane database and Scopus in August and September 2014 for topic of NAFLD in Asia and the way of prevention of this disease, with no language limitations. All relevant articles were accessed in full text and all relevant materials was evaluated and reviewed.
RESULTS: NAFLD is the most common liver disorder in worldwide, with an estimated with 20%-30% prevalence in Western countries and 2%-4% worldwide. The prevalence of NAFLD in Asia, depending on location (urban vs rural), gender, ethnicity, and age is variable between 15%-20%. According to the many studies in the world, the relationship between NAFLD, obesity, diabetes mellitus, and metabolic syndrome (MS) is quiet obvious. Prevalence of NAFLD in Asian countries seems to be lower than the Western countries but, it has increased recently due to the rise of obesity, type 2 diabetes and MS in this region. One of the main reasons for the increase in obesity, diabetes and MS in Asia is a lifestyle change and industrialization. Today, NAFLD is recognized as a major chronic liver disease in Asia. Therefore, prevention of this disease in Asian countries is very important and the best strategy for prevention and control of NAFLD is lifestyle modifications. Lifestyle modification programs are typically designed to change bad eating habits and increase physical activity that is associated with clinically significant improvements in obesity, type 2 diabetes and MS.
CONCLUSION: Prevention of NAFLD is very important in Asian countries particularly in Arab countries because of high prevalence of obesity, diabetes and MS.
Core tip: Today non-alcoholic fatty liver disease (NAFLD) is one of the main concerns of the medical world. NAFLD is identified as a main risk factor for chronic liver disease across the world. NAFLD is clearly linked with obesity, type 2 diabetes and metabolic syndrome (MS). The prevalence of NAFLD is lower in Asian countries than Western countries but, it has increased dramatically in recent years because of increasing rate of obesity, type 2 diabetes and MS in this region. The high prevalence of obesity with diabetes, and MS would increase the risk of NAFLD in recent years. So, prevention of these factors is the key strategy to reduce the incidence of NAFLD.