Sutti S, Jindal A, Bruzzì S, Locatelli I, Bozzola C, Albano E. Is there a role for adaptive immunity in nonalcoholic steatohepatitis? World J Hepatol 2015; 7(13): 1725-1729 [PMID: 26167244 DOI: 10.4254/wjh.v7.i13.1725]
Corresponding Author of This Article
Dr. Salvatore Sutti, Department of Health Science and Interdisciplinary Research Centre for Autoimmune Diseases, University “Amedeo Avogadro” of East Piedmont, Via Solaroli 17, 28100 Novara, Italy. salvatore.sutti@med.unipmn.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University “Amedeo Avogadro” of East Piedmont, 28100 Novara, Italy
Author contributions: Sutti S and Jindal A equally contributed to the work; all authors contributed to this manuscript.
Conflict-of-interest statement: Nothing to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Salvatore Sutti, Department of Health Science and Interdisciplinary Research Centre for Autoimmune Diseases, University “Amedeo Avogadro” of East Piedmont, Via Solaroli 17, 28100 Novara, Italy. salvatore.sutti@med.unipmn.it
Telephone: +39-0321-660650 Fax: +39-0321-620421
Received: January 13, 2015 Peer-review started: January 16, 2015 First decision: March 6, 2015 Revised: April 13, 2015 Accepted: April 28, 2015 Article in press: April 30, 2015 Published online: July 8, 2015 Processing time: 177 Days and 20.3 Hours
Abstract
The growing diffusion of nonalcoholic fatty liver disease (NAFLD) is a consequence of the worldwide increase in the prevalence of obesity. Oxidative stress is widely recognized to play a pivotal role in NAFLD evolution to nonalcoholic steatohepatitis (NASH). Here we review recent evidence suggesting that oxidative stress-derived antigens originating within fatty livers stimulate both humoral and cellular adaptive immune responses and the possible mechanisms involved in sustaining hepatic inflammation in NASH.
Core tip: Nonalcoholic fatty liver disease (NAFLD) is becoming one of the most common hepatic diseases, yet the factors responsible for the wide inter-individual variability in NAFLD evolution to nonalcoholic steatohepatitis are still poorly understood. In this Editorial, we comment on recent evidence suggesting the involvement of adaptive immune responses in sustaining hepatic inflammation during NAFLD evolution.
