Case Report
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World J Hepatol. Mar 27, 2014; 6(3): 155-159
Published online Mar 27, 2014. doi: 10.4254/wjh.v6.i3.155
Nested stromal-epithelial tumour of the liver: An unusual liver entity
Fabio Procopio, Luca Di Tommaso, Silvia Armenia, Vittorio Quagliuolo, Massimo Roncalli, Guido Torzilli
Fabio Procopio, Guido Torzilli, Department of Hepatobiliary Surgery, University of Milan, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
Luca Di Tommaso, Silvia Armenia, Massimo Roncalli, Department of Pathology, University of Milan, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
Vittorio Quagliuolo, Department of Surgical Oncology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
Author contributions: Procopio F wrote the manuscript; Di Tommaso L and Armenia S reviewed the anatomopathological data; Roncalli M and Torzilli G reviewed and approved the manuscript.
Correspondence to: Fabio Procopio, MD, Department of Hepatobiliary Surgery, University of Milan, Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy. procopio.fabio@gmail.com
Telephone: +39-2-82247278 Fax: +39-2-82244590
Received: October 2, 2013
Revised: December 16, 2013
Accepted: January 17, 2014
Published online: March 27, 2014
Processing time: 167 Days and 22.3 Hours
Abstract

Nested stromal-epithelial tumours (NSETs) of the liver have been reported to be extremely unusual primary hepatic neoplasms. To date, few cases have been described in the literature. NSETs have been defined as non-hepatocytic and non-biliary tumours of the liver consisting of nests of epithelial and spindled cells, myofibroblastic stroma and variable intralesional calcification and ossification. Here, we report a case of a young female who underwent liver resection for a large hepatic lesion that proved to be a calcifying NSET on pathological examination. Details about the clinical and histopathological features of the tumour are reported.

Keywords: Nested stromal-epithelial tumour; Hepatic tumour; Liver resection; Hepatic mixed tumour; Hepatectomy

Core tip: Rare cases of hepatic nested stromal-epithelial tumours (NSETs), consisting of non-hepatocytic mixed stromal and epithelial neoplasms with associated calcification and ossification, have been previously described. To date, NSETs’ behaviour and prognosis are completely unclear. We report the case of a 23-year-old female who underwent liver resection for a large hepatic, calcifying NSET. Details about preoperative imaging and the clinical and histopathological features of this very rare hepatic tumour are reported.