Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C

doi:10.4254/wjh.v2.i9.358

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 2, Issue 9

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2606)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

392

HTML

2214

Sum=2606

Sep 27, 2010 (publication date) through May 5, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Hepatol. Sep 27, 2010; 2(9): 358-361
Published online Sep 27, 2010. doi: 10.4254/wjh.v2.i9.358

Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C

Kazuaki Nishio, Takeshi Konndo, Shunichi Okada, Machiko Enchi

Kazuaki Nishio, Takeshi Konndo, The Third Department of Internal Medicine, School of Medicine Showa University, Tokyo 142-8666, Japan

Shunichi Okada, Department of Neurology, Toyoko Hospital, St. Marianna University, Kanagawa 211-0063, Japan

Machiko Enchi, Kawasaki Social Insurance Hospital, Kanagawa 210-0853, Japan

Author contributions: Nishio K and Konndo T were responsible for cardiology, Okada S for neurology and Enchi M for hepatology for this paper.

Correspondence to: Kazuaki Nishio, MD, PhD, The Third Department of Internal Medicine, School of Medicine Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. kazukun@jg7.so-net.ne.jp

Telephone: +81-44-288-2601 Fax: +81-44-299-1138

Received: March 22, 2010
Revised: August 15, 2010
Accepted: August 22, 2010
Published online: September 27, 2010

Abstract

We report a case of pericarditis and chronic inflammatory demyelinating polyneuropathy with biological signs of a lupus-like syndrome due to pegylated interferon alfa-2a therapy during treatment for chronic hepatitis C. The patient developed moderate weakness in the lower limbs and dyspnea. He was hospitalized for congestive heart failure. An electrocardiogram showed gradual ST-segment elevation in leads V₁ through V₆ without coronary artery disease. A transthoracic cardiac ultrasonographic study revealed moderate pericardial effusion with normal left ventricular function. Anti-DNA antibody and antids DNA IgM were positive. Neurological examination revealed a symmetrical predominantly sensory polyneuropathy with impairment of light touch and pin prick in globe and stoking-like distribution. Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.

Keywords: Chronic hepatitis C, Chronic inflammatory demyelinating polyneuropathy, Peginterferon alfa-2a, Pericarditis