Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C

doi:10.4254/wjh.v2.i9.358

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Sep 27, 2010 (publication date) through Feb 7, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Sep 27, 2010; 2(9): 358-361
Published online Sep 27, 2010. doi: 10.4254/wjh.v2.i9.358

Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C

Kazuaki Nishio, Takeshi Konndo, Shunichi Okada, Machiko Enchi

Kazuaki Nishio, Takeshi Konndo, The Third Department of Internal Medicine, School of Medicine Showa University, Tokyo 142-8666, Japan

Shunichi Okada, Department of Neurology, Toyoko Hospital, St. Marianna University, Kanagawa 211-0063, Japan

Machiko Enchi, Kawasaki Social Insurance Hospital, Kanagawa 210-0853, Japan

Author contributions: Nishio K and Konndo T were responsible for cardiology, Okada S for neurology and Enchi M for hepatology for this paper.

Correspondence to: Kazuaki Nishio, MD, PhD, The Third Department of Internal Medicine, School of Medicine Showa University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. kazukun@jg7.so-net.ne.jp

Telephone: +81-44-288-2601 Fax: +81-44-299-1138

Received: March 22, 2010
Revised: August 15, 2010
Accepted: August 22, 2010
Published online: September 27, 2010

Abstract

We report a case of pericarditis and chronic inflammatory demyelinating polyneuropathy with biological signs of a lupus-like syndrome due to pegylated interferon alfa-2a therapy during treatment for chronic hepatitis C. The patient developed moderate weakness in the lower limbs and dyspnea. He was hospitalized for congestive heart failure. An electrocardiogram showed gradual ST-segment elevation in leads V₁ through V₆ without coronary artery disease. A transthoracic cardiac ultrasonographic study revealed moderate pericardial effusion with normal left ventricular function. Anti-DNA antibody and antids DNA IgM were positive. Neurological examination revealed a symmetrical predominantly sensory polyneuropathy with impairment of light touch and pin prick in globe and stoking-like distribution. Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.

Keywords: Chronic hepatitis C; Chronic inflammatory demyelinating polyneuropathy; Peginterferon alfa-2a; Pericarditis