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World J Hepatol. Nov 27, 2010; 2(11): 416-418
Published online Nov 27, 2010. doi: 10.4254/wjh.v2.i11.416
Published online Nov 27, 2010. doi: 10.4254/wjh.v2.i11.416
Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon
Tomofumi Miura, Nobuaki Suzuki, Junichiro Nakamura, Satoshi Yamada, Tsutomu Miura, Masahiko Yanagi, Toru Takahashi, Division of Gastroenterology and Hepatology, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan
Hiroyuki Usuda, Division of Medical Technology, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan
Iwao Emura, Division of Pathology, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan
Author contributions: Miura T, Suzuki N, Nakamura J, Yamada S, Miura T, Yanagi M and Takahashi T wrote the paper; and Usuda H and Emura I engaged in the pathological examination of the patient.
Correspondence to: Tomofumi Miura, MD, Division of Gastroenterology and Hepatology, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan. miuratom@nagaoka.jrc.or.jp
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Received: May 18, 2010
Revised: November 5, 2010
Accepted: November 12, 2010
Published online: November 27, 2010
Revised: November 5, 2010
Accepted: November 12, 2010
Published online: November 27, 2010
Abstract
Hepatocarcinogenesis after a sustained virological response (SVR) in type C chronic hepatitis and cirrhosis is an important issue in endemic areas; hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) therapy is especially very hard. We herein report a first case in which combination therapy with interferon-α and continuous intra-arterial infusion of 5-fluorouracil (designated as FAIT) provided a complete response in HCC with PVTT after SVR. Therefore, we think that FAIT is a good option to treat HCC with or without PVTT, even after SVR.
Keywords: Hepatocellular carcinoma; Portal vein tumor thrombus; Sustained virological response; 5-Fluorouracil intra-arterial infusion