Pan Y, Jiao FY. Relationship between Kawasaki disease and alanine aminotransferase levels in pediatric patients. World J Hepatol 2025; 17(2): 98840 [DOI: 10.4254/wjh.v17.i2.98840]
Corresponding Author of This Article
Fu-Yong Jiao, PhD, Senior Scientist, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children's Hospital, Shaanxi Provincial People's Hospital of Xi'an Jiaotong University, No. 256 Youyi West Road, Beilin District, Xi'an 710000, Shaanxi Province, China. 3105089948@qq.com
Research Domain of This Article
Hematology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Feb 27, 2025; 17(2): 98840 Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.98840
Relationship between Kawasaki disease and alanine aminotransferase levels in pediatric patients
Yan Pan, Fu-Yong Jiao
Yan Pan, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Fu-Yong Jiao, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children's Hospital, Shaanxi Provincial People's Hospital of Xi'an Jiaotong University, Xi'an 710000, Shaanxi Province, China
Author contributions: Pan Y and Jiao FY contributed equally to the conception, writing and editing of this manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Yong Jiao, PhD, Senior Scientist, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children's Hospital, Shaanxi Provincial People's Hospital of Xi'an Jiaotong University, No. 256 Youyi West Road, Beilin District, Xi'an 710000, Shaanxi Province, China. 3105089948@qq.com
Received: July 7, 2024 Revised: January 16, 2025 Accepted: February 6, 2025 Published online: February 27, 2025 Processing time: 227 Days and 16.1 Hours
Abstract
Kawasaki disease (KD) is a critical pediatric vasculitis with potentially severe cardiovascular outcomes if left untreated. Alanine aminotransferase (ALT) levels, which primarily indicate hepatic injury, are frequently elevated in patients with KD, suggesting systemic inflammation and liver involvement. This editorial explores the multifaceted relationship between KD and ALT elevation, emphasizing the importance of monitoring ALT levels to gauge disease severity and tailor therapeutic interventions. The comprehensive evaluation and integration of ALT monitoring into routine clinical practice can improve patient outcomes by identifying high-risk patients early and guiding timely and appropriate management strategies.
Core Tip: Kawasaki disease (KD) is a severe pediatric vasculitis that can lead to significant cardiovascular complications if untreated. Elevated alanine aminotransferase (ALT) levels are commonly observed in KD patients, indicating systemic inflammation and liver involvement. Monitoring ALT levels is crucial for assessing disease severity and tailoring personalized treatment interventions. Elevated ALT may indicate broader systemic inflammation and higher risk of complications. Integrating ALT monitoring into routine clinical practice helps in early identification of high-risk patients and timely, appropriate management, ultimately improving patient outcomes.
