Zhang JG, Wang YW, Wang QY, Wen B. Clinical features and risk factors for combined Klebsiella pneumoniae infection in patients with liver cirrhosis. World J Hepatol 2025; 17(2): 103648 [DOI: 10.4254/wjh.v17.i2.103648]
Corresponding Author of This Article
Biao Wen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, No. 312 Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jian-Guo Zhang, Yan-Wei Wang, Qiong-Ya Wang, Biao Wen, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China
Author contributions: Zhang JG wrote and approved the final draft of the manuscript; Wang YW conceptualized and designed the framework of this manuscript; Wang QY conducted a comprehensive search for references; Wen B revised the manuscript; and all authors have read and approved the final manuscript.
Supported by the Key Research and Development Project of the Science and Technology Department of Sichuan Province, China, No. 2023YFS0280; the High-level Research Initiation Fund Program of the First Affiliated Hospital of Chengdu Medical College, China, No. CYFY-GQ43.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Biao Wen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, No. 312 Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com
Received: November 29, 2024 Revised: January 23, 2025 Accepted: February 6, 2025 Published online: February 27, 2025 Processing time: 83 Days and 23 Hours
Abstract
This article discusses the findings presented by Zhang et al. They analyzed the risk factors and clinical characteristics associated with Klebsiella pneumoniae infection in patients with liver cirrhosis treated at a hospital in Beijing. In this article, we focus on the connection between chronic kidney disease and the intestinal microbiota, and propose microbiota transplantation as a potential treatment for this patient group. We also examine an intriguing phenomenon related to hepatic encephalopathy, and provide insights into the future research.
Core Tip: Cirrhosis complicated by Klebsiella pneumoniae infection significantly affects patient prognosis. Distinct clinical features were observed between the death and improvement groups, and understanding these differences could enhance clinical management of this disease. Fecal microbiota transplantation holds promise as a potential treatment for these patients. Further in-depth studies are essential to improve our understanding of this disease and to optimize patient outcomes.
