Willington AJ, Tripathi D. Current concepts in the management of non-cirrhotic non-malignant portal vein thrombosis. World J Hepatol 2024; 16(5): 751-765 [PMID: 38818283 DOI: 10.4254/wjh.v16.i5.751]
Corresponding Author of This Article
Dhiraj Tripathi, FRCP, MD, Professor, Department of Hepatology, University Hospitals Birmingham, Mindelsohn Way, Birmingham B15 2TH, United Kingdom. dhiraj.tripathi@uhb.nhs.uk
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. May 27, 2024; 16(5): 751-765 Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.751
Current concepts in the management of non-cirrhotic non-malignant portal vein thrombosis
Adam J Willington, Dhiraj Tripathi
Adam J Willington, Department of Hepatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, United Kingdom
Dhiraj Tripathi, Department of Hepatology, University Hospitals Birmingham, Birmingham B15 2TH, United Kingdom
Author contributions: Willington AJ wrote the manuscript; Willington AJ and Tripathi D equally contributed to the concept and revising the manuscript.
Supported by Speaker honorarium from WL Gore & Associates.
Conflict-of-interest statement: Adam J Willington – no conflicts of interest. Dhiraj Tripathi – Speaker honorarium from WL Gore & Associates.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dhiraj Tripathi, FRCP, MD, Professor, Department of Hepatology, University Hospitals Birmingham, Mindelsohn Way, Birmingham B15 2TH, United Kingdom. dhiraj.tripathi@uhb.nhs.uk
Received: November 17, 2023 Revised: February 20, 2024 Accepted: April 8, 2024 Published online: May 27, 2024
Abstract
Non-cirrhotic non-malignant portal vein thrombosis (NCPVT) is an uncommon condition characterised by thrombosis of the portal vein, with or without extension into other mesenteric veins, in the absence of cirrhosis or intra-abdominal malignancy. Complications can include intestinal infarction, variceal bleeding and portal biliopathy. In this article, we address current concepts in the management of NCPVT including identification of risk factors, classification and treatment, and review the latest evidence on medical and interventional management options.
Core Tip: The successful management of patients with non-cirrhotic non-malignant portal vein thrombosis (NCPVT) requires clinicians to diagnose and classify the condition correctly, meticulously identify underlying risk factors and select the appropriate treatment strategies based on the latest supporting evidence. Herein we provide a comprehensive review of current concepts in the management of NCPVT with suggested management algorithms.
