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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Non-alcoholic fatty liver disease and sleep disorders
Lu-Fang Bu, Chong-Yu Xiong, Jie-Yi Zhong, Yan Xiong, Dong-Ming Li, Fen-Fang Hong, Shu-Long Yang
Lu-Fang Bu, Chong-Yu Xiong, Jie-Yi Zhong, Yan Xiong, Dong-Ming Li, Shu-Long Yang, Department of Physiology, Fuzhou Medical College, Nanchang University, Fuzhou 344000, Jiangxi Province, China
Lu-Fang Bu, Chong-Yu Xiong, Jie-Yi Zhong, Yan Xiong, Dong-Ming Li, Shu-Long Yang, Key Laboratory of Chronic Diseases, Fuzhou Medical University, Fuzhou 344000, Jiangxi Province, China
Lu-Fang Bu, Chong-Yu Xiong, Jie-Yi Zhong, Yan Xiong, Dong-Ming Li, Shu-Long Yang, Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344000, Jiangxi Province, China
Fen-Fang Hong, Experimental Center of Pathogen Biology, College of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Bu LF wrote the manuscript and designed the table; Xiong CY revised the manuscript and designed the figure; Zhong JY, Xiong Y were responsible for data collection; Li DM, Hong FF and Yang SL are co-corresponding authors who contributed equally to this work, and are responsible for improving the grammar and language, conceptualizing the idea, and obtaining funding; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82360880, and 82060661; Jiangxi Provincial Natural Science Foundation of China, No. 20232ACB206057; Key project of Jiangxi Provincial Department of Education, No. GJJ218104; Teaching reform research project of Jiangxi Province of China, No. JXJG-22-130-1; National Natural Science Foundation of China, No. 81660151; and Jiangxi Provincial Natural Science Foundation of China, No. 20212BAB206092.
Conflict-of-interest statement: All authors have no relevant conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Shu-Long Yang, Doctor, School of Basic Medical Sciences and Key Laboratory of Chronic Diseases, Fuzhou Medical College of Nanchang University, No. 461 Bayi Avenue, Fuzhou 344000, Jiangxi Province, China. Shulongyang@qq.com
Received: October 20, 2023
Peer-review started: October 20, 2023
First decision: December 25, 2023
Revised: January 11, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 27, 2024
Processing time: 159 Days and 1.4 Hours
Studies have shown that non-alcoholic fatty liver disease (NAFLD) may be associated with sleep disorders. In order to explore the explicit relationship between the two, we systematically reviewed the effects of sleep disorders, especially obstructive sleep apnea (OSA), on the incidence of NAFLD, and analyzed the possible mechanisms after adjusting for confounding factors. NAFLD is independently associated with sleep disorders. Different sleep disorders may be the cause of the onset and aggravation of NAFLD. An excessive or insufficient sleep duration, poor sleep quality, insomnia, sleep-wake disorders, and OSA may increase the incidence of NAFLD. Despite that some research suggests a unidirectional causal link between the two, specifically, the onset of NAFLD is identified as a result of changes in sleep characteristics, and the reverse relationship does not hold true. Nevertheless, there is still a lack of specific research elucidating the reasons behind the higher risk of developing sleep disorders in individuals with NAFLD. Further research is needed to establish a clear relationship between NAFLD and sleep disorders. This will lay the groundwork for earlier identification of potential patients, which is crucial for earlier monitoring, diagnosis, effective prevention, and treatment of NAFLD.
Core Tip: Non-alcoholic fatty liver disease (NAFLD) is independently associated with sleep disorders. Different sleep disorders may be the cause of the onset and aggravation of NAFLD. An excessive or insufficient sleep duration, poor sleep quality, insomnia, sleep-wake-disorders, particularly obstructive sleep apnea, may increase the incidence of NAFLD and contribute to its development and worsening. Further research is needed to establish a clear relationship between NAFLD and sleep disorders, which can help identify potential patients earlier and facilitate effective prevention and treatment measures.
