Chang M, Wang SY, Zhang ZY, Hao HX, Li XG, Li JJ, Xie Y, Li MH. Pituitary stalk interruption syndrome complicated with liver cirrhosis: A case report. World J Hepatol 2024; 16(11): 1348-1355 [DOI: 10.4254/wjh.v16.i11.1348]
Corresponding Author of This Article
Ming-Hui Li, PhD, Chief Doctor, Professor, Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing 100015, China. wuhm2000@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Nov 27, 2024; 16(11): 1348-1355 Published online Nov 27, 2024. doi: 10.4254/wjh.v16.i11.1348
Pituitary stalk interruption syndrome complicated with liver cirrhosis: A case report
Min Chang, Shi-Yu Wang, Zi-Yu Zhang, Hong-Xiao Hao, Xin-Gang Li, Jing-Jing Li, Yao Xie, Ming-Hui Li
Min Chang, Shi-Yu Wang, Zi-Yu Zhang, Hong-Xiao Hao, Yao Xie, Ming-Hui Li, Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Xin-Gang Li, Department of Endocrinology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Jing-Jing Li, Department of Radiology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Ming-Hui Li, Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing 100015, China
Co-first authors: Min Chang and Shi-Yu Wang.
Author contributions: Li MH and Chang M participated in the conceptualization and design of the study; Chang M and Wang SY wrote the first English manuscript; Zhang ZY and Hao HX collected all data and managed the patient; Xie Y contributed to data analysis; Li XG assisted in the diagnosis of the patient’s disease; Li JJ provided imaging materials; Chang M and Wang SY contribute equally to this study as co-first authors.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Hui Li, PhD, Chief Doctor, Professor, Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing 100015, China. wuhm2000@sina.com
Received: May 22, 2024 Revised: August 18, 2024 Accepted: September 14, 2024 Published online: November 27, 2024 Processing time: 167 Days and 17.8 Hours
Abstract
BACKGROUND
Pituitary stalk interruption syndrome (PSIS) is a rare disorder, often characterized by delayed growth and development, short stature, and hypogonadism as the main clinical manifestations. It is not clear whether PSIS can lead to liver cirrhosis.
CASE SUMMARY
This paper reported a case of liver cirrhosis of unknown origin. The patient was admitted to Beijing Ditan Hospital Affiliated to Capital Medical University in November 2023. The diagnosis of PSIS complicated with liver cirrhosis was established after a series of blood tests and pituitary magnetic resonance imaging examination.
CONCLUSION
We also reviewed the literature from both domestic and international sources to deepen the clinical understanding of PSIS in conjunction with liver cirrhosis among medical practitioners.
Core Tip: Our patient with pituitary stalk interruption syndrome (PSIS) showed a general decrease of anterior pituitary hormones and typical imaging findings. We excluded liver cirrhosis by other causes. The patient did not receive any treatment for many years, which may represent the natural progression of this disease and included rare cases of osteoporosis and cirrhosis. Liver cirrhosis caused by PSIS is very rare in clinical practice, and hepatologists should be alert to PSIS when encountering patients with liver cirrhosis complicated with abnormal growth and development.
