Garrido I, Lopes S, Fonseca E, Carneiro F, Macedo G. Autoimmune hepatitis and eosinophilia: A rare case report. World J Hepatol 2023; 15(2): 311-317 [PMID: 36926232 DOI: 10.4254/wjh.v15.i2.311]
Corresponding Author of This Article
Isabel Garrido, MD, Doctor, Department of Gastroenterology and Hepatology, Centro Hospitalar Universitário de São João; World Gastroenterology Organization Porto Training Center; Faculty of Medicine of the University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal. isabelmng@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Isabel Garrido, Susana Lopes, Guilherme Macedo, Department of Gastroenterology and Hepatology, Centro Hospitalar Universitário de São João; World Gastroenterology Organization Porto Training Center; Faculty of Medicine of the University of Porto, Porto, Portugal
Elsa Fonseca, Fátima Carneiro, Department of Pathology, Centro Hospitalar Universitário de São João; Instituto de Investigação e Inovação em Saúde (i3S) and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup); Faculty of Medicine of the University of Porto, Porto, Portugal
Author contributions: Garrido I did literature review and drafted the manuscript; Garrido I, Lopes S, Fonseca E, Carneiro F, and Macedo G have critically revised and finalized the manuscript; All authors have approved the final version of the manuscript.
Informed consent statement: The patient signed informed consent.
Conflict-of-interest statement: All the authors have no disclosures to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Isabel Garrido, MD, Doctor, Department of Gastroenterology and Hepatology, Centro Hospitalar Universitário de São João; World Gastroenterology Organization Porto Training Center; Faculty of Medicine of the University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal. isabelmng@hotmail.com
Received: November 1, 2022 Peer-review started: November 1, 2022 First decision: December 13, 2022 Revised: December 13, 2022 Accepted: January 5, 2023 Article in press: January 5, 2023 Published online: February 27, 2023 Processing time: 114 Days and 20.3 Hours
Abstract
BACKGROUND
Autoimmune hepatitis consists of a chronic liver disease whose etiology is unknown. It is comprised of relevant immunological aspects and of immune-mediated liver injury. Eosinophilia may be a considerable feature, particularly happening in male patients.
CASE SUMMARY
We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia, circulating autoantibodies and elevated transaminase levels. He also had significant peripheral eosinophilia and elevated immunoglobulin E levels at diagnosis. The pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic infiltration.
CONCLUSION
This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow, described in a patient with Crohn’s disease.
Core Tip: There are very few reported cases of autoimmune hepatitis presenting with peripheral blood eosinophilia. This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow, described in a patient with Crohn’s disease.
