Published online Nov 27, 2023. doi: 10.4254/wjh.v15.i11.1210
Peer-review started: July 26, 2023
First decision: August 16, 2023
Revised: August 29, 2023
Accepted: October 30, 2023
Article in press: October 30, 2023
Published online: November 27, 2023
Processing time: 121 Days and 0.5 Hours
Nonalcoholic fatty liver disease (NAFLD) has become the leading cause of cirrhosis and other chronic liver diseases (COCLDs).
To conduct a comprehensive and comparable updated analysis of the global, regional, and national burden of COCLDs due to NAFLD in 204 countries and territories from 1990 and 2019 by age, sex, and sociodemographic index.
Data on COCLDs due to NAFLD were collected from the Global Burden of Disea
In 2019, the global age-standardized prevalence rate of COCLDs due to NAFLD was 15022.90 per 100000 population [95% uncertainty interval (UI): 13493.19-16764.24], which increased by 24.51% (22.63% to 26.08%) from 1990, with an estimated annual percentage change of 0.78 (95% confidence interval: 0.74-0.82). In the same year, however, the age-standardized death rate and age-standardized DALYs per 100000 population were 1.66 (95%UI: 1.20-2.17) and 43.69 (95%UI: 31.28-58.38), respectively. North Africa and the Middle East had the highest prevalence rates of COCLDs due to NAFLD. The death rate increased with age up to the 95+ age group for both sexes. Males had higher numbers of prevalence, death rate, and DALYs than females across all age groups before the 65-69 age group. The sociodemographic index was negatively correlated with the age-standardized DALYs.
Globally, the age-standardized prevalence rate has increased during the past three decades. However, the age-standardized death rate and age-standardized DALYs decreased. There is geographical variation in the burden of COCLDs due to NAFLD. It is strongly recommended to improve the data quality of COCLDs due to NAFLD across all countries and regions to facilitate better monitoring of the burden of COCLDs due to NAFLD.
Core Tip: Nonalcoholic fatty liver disease is the leading cause of cirrhosis and other chronic liver diseases. The global age-standardized prevalence rate of cirrhosis and other chronic liver diseases due to nonalcoholic fatty liver disease increased by 24.51% from 1990. The age-standardized death rate and age-standardized disability-adjusted life-years rate per 100000 population were 1.66 and 43.69, respectively. The highest prevalence rate was observed in North Africa and the Middle East. Males had a higher burden of prevalence, death, and disability-adjusted life-years lost than females before the 65-69 age group. Furthermore, there is a negative correlation between sociodemographic index and age-standardized death rate.