Obed A, Bashir A, Jarrad A, Fuzesi L. Role of biliary complications in chronic graft rejection after living donor liver transplantation. World J Hepatol 2022; 14(5): 1050-1052 [PMID: 35721291 DOI: 10.4254/wjh.v14.i5.1050]
Corresponding Author of This Article
Aiman Obed, FACS, FEBS, MD, Associate Professor, Doctor, Surgeon, Surgical Oncologist, Hepatobiliary and Liver Transplant Unit, Jordan Hospital, Queen Noor Street, Amman 52112, Jordan. aimanobed@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Aiman Obed, Hepatobiliary and Liver Transplant Unit, Jordan Hospital, Amman 52112, Jordan
Abdalla Bashir, Department of General Surgery, Jordan Hospital, Amman 52112, Jordan
Anwar Jarrad, Department of Hepatology, Jordan Hospital, Amman 52112, Jordan
Laszlo Fuzesi, Department of Pathology, Faculty of Medicine, University Augsburg, Augsburg 86156, Germany
Author contributions: Obed A designed the research; Obed A, Füzesi L, and Jarrad A performed research and revised the letter; Bashir A and Obed A analyzed the data; Obed A and Bashir A wrote the letter.
Conflict-of-interest statement: The authors declare no funding or conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aiman Obed, FACS, FEBS, MD, Associate Professor, Doctor, Surgeon, Surgical Oncologist, Hepatobiliary and Liver Transplant Unit, Jordan Hospital, Queen Noor Street, Amman 52112, Jordan. aimanobed@hotmail.com
Received: January 8, 2022 Peer-review started: January 8, 2022 First decision: February 8, 2022 Revised: February 14, 2022 Accepted: April 28, 2022 Article in press: April 28, 2022 Published online: May 27, 2022
Abstract
Postoperative biliary complications remain a substantial challenge after living donor liver transplantation, especially due to its heterogeneous clinical presentation.
Core Tip: In clinical practice, post-transplant cholangiopathy is a multifactorial process, including not only biliary complications like biliary leakage, biliary infection and biliary stricture, idiopathic post-transplant chronic hepatitis, fibrosing cholestatic hepatitis, and viral infections like cytomegalovirus but also chronic graft rejection. The post-transplant cholangiopathy substantially influences graft, as well as patient outcome and survival. Therefore, it is of outmost importance to distinguish the underlying etiology while simultaneously appreciating the heterogeneous nature of post-transplant cholangiopathy. A better understanding of clinical and histopathological features can result in an improved therapy strategy.
