Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1991
Peer-review started: March 28, 2021
First decision: June 15, 2021
Revised: July 27, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 27, 2021
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new acronym adopted from the consensus of international experts. Given the increasing prevalence of MAFLD in pre-transplant settings, de novo and recurrent graft steatosis/MAFLD are common in post-transplant settings. The impact of graft steatosis on long-term outcomes is unclear. The current knowledge of incidence rate, risk factors, diagnosis, long-term outcomes, and management of graft steatosis (both de novo and recurrent) is discussed in this review.
Core Tip: Metabolic dysfunction-associated fatty liver disease (MAFLD) is common after liver transplantation. Post transplant metabolic dysfunction, obesity and consequences of immunosuppressant contribute to the development of either de novo or recurrent graft steatosis. Post liver transplant MAFLD impact on cardiovascular outcome without significant impact on graft and patient survival. Weight control and tailoring of immunosuppression are the main strategies to prevent post liver transplant MAFLD.