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World J Hepatol. Oct 27, 2021; 13(10): 1316-1327
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1316
Pediatric vascular tumors of the liver: Review from the pathologist’s point of view
Fleur Cordier, Anne Hoorens, Jo Van Dorpe, David Creytens
Fleur Cordier, Anne Hoorens, Jo Van Dorpe, David Creytens, Department of Pathology, Ghent University Hospital, Ghent University, Ghent 9000, Belgium
Author contributions: Cordier F performed the writing of the paper; Creytens D, Hoorens A, and Van Dorpe J performed the study concept, design and review of the paper; All authors read and approved the final paper.
Conflict-of-interest statement: The authors state that there are no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: David Creytens, PhD, Academic Research, Chief Doctor, Professor, Department of Pathology, Ghent University Hospital, Ghent University, Corneel Heymanslaan 10, Ghent 9000, Belgium. david.creytens@uzgent.be
Received: February 26, 2021
Peer-review started: February 26, 2021
First decision: May 3, 2021
Revised: May 10, 2021
Accepted: August 27, 2021
Article in press: August 27, 2021
Published online: October 27, 2021
Processing time: 237 Days and 18.6 Hours
Abstract

Differential diagnosis of pediatric vascular liver tumors can be challenging due to inconsistent nomenclature, histologic overlap and the rarity of some entities. Here we give an up-to-date overview of the most important entities. We discuss the clinic, histology and pathophysiology of hepatic congenital and infantile heman gioma, hepatic epithelioid hemangioendothelioma and hepatic angiosarcoma.

Keywords: Hepatic congenital hemangioma; Hepatic infantile hemangioma; Hepatic epithelioid hemangioendothelioma; Hepatic angiosarcoma; Hepatic vascular tumors of infancy; Hepatic hemangiomas

Core Tip: Overview of the most important pediatric hepatic vascular tumors from the point of view of the pathologist, including hepatic hemangiomas, hepatic epithelioid hemangioendothelioma and hepatic angiosarcoma.